Chemical strategies for the presentation and delivery of growth factors

Jordi Cabanas Danés, Jurriaan Huskens, Pascal Jonkheijm

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
335 Downloads (Pure)

Abstract

Since the first demonstration of employing growth factors (GFs) to control cell behaviour in vitro, the spatiotemporal availability of GFs in vivo has received continuous attention. In particular, the ability to physically confine the mobility of GFs has been used in various tissue engineering applications e.g. stents, orthopaedic implants, sutures and contact lenses. The lack of control over the mobility of GFs in scaffolds jeopardizes their performance in vivo. In this feature article, an overview is given on how to effectively present GFs on scaffolds. In the first part, non-covalent strategies are described covering interaction motifs that are generic to direct GF immobilization. In the second part, covalent strategies are described emphasizing the introduction of reactive groups in existing biomaterials. The feature article ends with a description of strategies based on the physical entrapment of growth factors.
Original languageEnglish
Pages (from-to)2381-2394
Number of pages14
JournalJournal of materials chemistry. B: materials for biology and medicine
Volume2
Issue number17
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-308498
  • IR-95098

Fingerprint Dive into the research topics of 'Chemical strategies for the presentation and delivery of growth factors'. Together they form a unique fingerprint.

  • Cite this