Chemically driven switches for online detection of pH changes in microfluidic devices

P. Mela; S. Onclin; M.H. Goedbloed; S. Levi; N.F. van Hulst; Albert van den Berg

Chemically driven switches for online detection of pH changes in microfluidic devices

P. Mela, S. Onclin, M.H. Goedbloed, S. Levi, N.F. van Hulst, Albert van den Berg

Optical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.

Original language	English
Title of host publication	Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS)
Place of Publication	Braga, Portugal
Publisher	Barbarosa & Xavier
Pages	21-22
Number of pages	2
ISBN (Print)	972-98603-1-9
Publication status	Published - 2003
Event	Eurosensors XVII, European Conference on Solid-State Transducers - Guimaraes, Portugal Duration: 21 Sept 2003 → 24 Sept 2003

Conference

Conference	Eurosensors XVII, European Conference on Solid-State Transducers
Country/Territory	Portugal
City	Guimaraes
Period	21/09/03 → 24/09/03

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title = "Chemically driven switches for online detection of pH changes in microfluidic devices",

abstract = "The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.",

author = "P. Mela and S. Onclin and M.H. Goedbloed and S. Levi and {van Hulst}, N.F. and {van den Berg}, Albert",

year = "2003",

language = "English",

isbn = "972-98603-1-9",

pages = "21--22",

booktitle = "Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS)",

publisher = "Barbarosa & Xavier",

note = "Eurosensors XVII, European Conference on Solid-State Transducers ; Conference date: 21-09-2003 Through 24-09-2003",

}

Mela, P, Onclin, S, Goedbloed, MH, Levi, S, van Hulst, NF & van den Berg, A 2003, Chemically driven switches for online detection of pH changes in microfluidic devices. in Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS). Barbarosa & Xavier, Braga, Portugal, pp. 21-22, Eurosensors XVII, European Conference on Solid-State Transducers, Guimaraes, Portugal, 21/09/03.

Chemically driven switches for online detection of pH changes in microfluidic devices. / Mela, P.; Onclin, S.; Goedbloed, M.H. et al.
Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS). Braga, Portugal: Barbarosa & Xavier, 2003. p. 21-22.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Chemically driven switches for online detection of pH changes in microfluidic devices

AU - Mela, P.

AU - Onclin, S.

AU - Goedbloed, M.H.

AU - Levi, S.

AU - van Hulst, N.F.

AU - van den Berg, Albert

PY - 2003

Y1 - 2003

N2 - The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.

AB - The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.

M3 - Conference contribution

SN - 972-98603-1-9

SP - 21

EP - 22

BT - Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS)

PB - Barbarosa & Xavier

CY - Braga, Portugal

T2 - Eurosensors XVII, European Conference on Solid-State Transducers

Y2 - 21 September 2003 through 24 September 2003

ER -

Chemically driven switches for online detection of pH changes in microfluidic devices

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