Chemically driven switches for online detection of pH changes in microfluidic devices

P. Mela, S. Onclin, M.H. Goedbloed, S. Levi, N.F. van Hulst, Albert van den Berg

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Abstract

The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.
Original languageEnglish
Title of host publicationProceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS)
Place of PublicationBraga, Portugal
PublisherBarbarosa & Xavier
Pages21-22
Number of pages2
ISBN (Print)972-98603-1-9
Publication statusPublished - 2003
EventEurosensors XVII, European Conference on Solid-State Transducers - Guimaraes, Portugal
Duration: 21 Sep 200324 Sep 2003

Conference

ConferenceEurosensors XVII, European Conference on Solid-State Transducers
CountryPortugal
CityGuimaraes
Period21/09/0324/09/03

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    Mela, P., Onclin, S., Goedbloed, M. H., Levi, S., van Hulst, N. F., & van den Berg, A. (2003). Chemically driven switches for online detection of pH changes in microfluidic devices. In Proceedings of the 17th European Conference on Solid-State Transducers (EUROSENSORS) (pp. 21-22). Braga, Portugal: Barbarosa & Xavier.