Chemically modified field effect transistors: the effect of ion-pair association on the membrane potentials

P.L.H.M. Cobben, Peter L.H.M. Cobben, Richard J.M. Egberink, Johan G. Bomer, Piet Bergveld, David Reinhoudt

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Abstract

A theoretical model has been developed which relates physically accessible parameters to the formation of a membrane potential. The description is an extension of a theoretical description presented previously by our group, now including divalent cations and ion-pair association. Simulations of the overall membrane potential reveal several factors that may lead to non-Nernstian response curves. For monovalent and divalent cations a reduction in the slope of the response curve (sub-Nernstian response) should virtually always be expected when ion-pair association takes place in the membrane. Ion-pair association of divalent cations and sample anions can lead to a super-Nernstian response. A diffusion potential generally reduces the Nernstian slope of the response curve. In addition, several experimental results are described which illustrate and confirm our theoretical model.
Original languageUndefined
Pages (from-to)193-208
JournalJournal of electroanalytical chemistry
Volume368
Issue number368
DOIs
Publication statusPublished - 1994

Keywords

  • METIS-106615
  • IR-15069

Cite this

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title = "Chemically modified field effect transistors: the effect of ion-pair association on the membrane potentials",
abstract = "A theoretical model has been developed which relates physically accessible parameters to the formation of a membrane potential. The description is an extension of a theoretical description presented previously by our group, now including divalent cations and ion-pair association. Simulations of the overall membrane potential reveal several factors that may lead to non-Nernstian response curves. For monovalent and divalent cations a reduction in the slope of the response curve (sub-Nernstian response) should virtually always be expected when ion-pair association takes place in the membrane. Ion-pair association of divalent cations and sample anions can lead to a super-Nernstian response. A diffusion potential generally reduces the Nernstian slope of the response curve. In addition, several experimental results are described which illustrate and confirm our theoretical model.",
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year = "1994",
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Chemically modified field effect transistors: the effect of ion-pair association on the membrane potentials. / Cobben, P.L.H.M.; Cobben, Peter L.H.M.; Egberink, Richard J.M.; Bomer, Johan G.; Bergveld, Piet; Reinhoudt, David.

In: Journal of electroanalytical chemistry, Vol. 368, No. 368, 1994, p. 193-208.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Chemically modified field effect transistors: the effect of ion-pair association on the membrane potentials

AU - Cobben, P.L.H.M.

AU - Cobben, Peter L.H.M.

AU - Egberink, Richard J.M.

AU - Bomer, Johan G.

AU - Bergveld, Piet

AU - Reinhoudt, David

PY - 1994

Y1 - 1994

N2 - A theoretical model has been developed which relates physically accessible parameters to the formation of a membrane potential. The description is an extension of a theoretical description presented previously by our group, now including divalent cations and ion-pair association. Simulations of the overall membrane potential reveal several factors that may lead to non-Nernstian response curves. For monovalent and divalent cations a reduction in the slope of the response curve (sub-Nernstian response) should virtually always be expected when ion-pair association takes place in the membrane. Ion-pair association of divalent cations and sample anions can lead to a super-Nernstian response. A diffusion potential generally reduces the Nernstian slope of the response curve. In addition, several experimental results are described which illustrate and confirm our theoretical model.

AB - A theoretical model has been developed which relates physically accessible parameters to the formation of a membrane potential. The description is an extension of a theoretical description presented previously by our group, now including divalent cations and ion-pair association. Simulations of the overall membrane potential reveal several factors that may lead to non-Nernstian response curves. For monovalent and divalent cations a reduction in the slope of the response curve (sub-Nernstian response) should virtually always be expected when ion-pair association takes place in the membrane. Ion-pair association of divalent cations and sample anions can lead to a super-Nernstian response. A diffusion potential generally reduces the Nernstian slope of the response curve. In addition, several experimental results are described which illustrate and confirm our theoretical model.

KW - METIS-106615

KW - IR-15069

U2 - 10.1016/0022-0728(93)03114-5

DO - 10.1016/0022-0728(93)03114-5

M3 - Article

VL - 368

SP - 193

EP - 208

JO - Journal of electroanalytical chemistry

JF - Journal of electroanalytical chemistry

SN - 0368-1874

IS - 368

ER -