TY - JOUR
T1 - Chemistry: A light-actuated nanovalve derived from a channel protein
AU - Koçer, Armaǧan
AU - Walko, Martin
AU - Meijberg, Wim
AU - Feringa, Ben L.
PY - 2005
Y1 - 2005
N2 - Toward the realization of nanoscale device control, we report a molecular valve embedded in a membrane that can be opened by illumination with long-wavelength ultraviolet (366 nanometers) light and then resealed by visible irradiation. The valve consists of a channel protein, the mechanosensitive channel of large conductance (MscL) from Escherichia coli, modified by attachment of synthetic compounds that undergo light-induced charge separation to reversibly open and close a 3-nanometer pore. The system is compatible with a classical encapsulation system, the liposome, and external photochemical control over transport through the channel is achieved.
AB - Toward the realization of nanoscale device control, we report a molecular valve embedded in a membrane that can be opened by illumination with long-wavelength ultraviolet (366 nanometers) light and then resealed by visible irradiation. The valve consists of a channel protein, the mechanosensitive channel of large conductance (MscL) from Escherichia coli, modified by attachment of synthetic compounds that undergo light-induced charge separation to reversibly open and close a 3-nanometer pore. The system is compatible with a classical encapsulation system, the liposome, and external photochemical control over transport through the channel is achieved.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-23044503853&partnerID=MN8TOARS
U2 - 10.1126/science.1114760
DO - 10.1126/science.1114760
M3 - Article
SN - 0036-8075
VL - 309
SP - 755
EP - 758
JO - Science
JF - Science
IS - 5735
ER -