Chemistry of 4-membered cyclic nitrones (2, 3-dihydroazete 1-oxides); a novel one-step synthesis of N-acetoxy β-latams

M.L.M. Pennings, David Reinhoudt

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Abstract

2,3-dihydroazete 1-oxide 1 reacts at room temperature with base, acid and lead tetraacetate to give the 5-hydroxyisoxazolidines 4a and 4b , the 6H-1,2-oxazin-6-one 7 and the N-acetoxy β-lactam 8, respectively; the reaction with lead tetraacetate represents a simple one-step conversion of a 4-membered cyclic nitrone into a β-lactam.
Original languageUndefined
Pages (from-to)1153-1156
JournalTetrahedron letters
Volume22
Issue number12
DOIs
Publication statusPublished - 1981

Keywords

  • IR-68750

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