Chip-based on-line nanospray MS method enabling study of the kinetics of isocyanate derivatization reactions

M. Brivio, A. Liesener, R.E. Oosterbroek, Willem Verboom, U. Karst, Albert van den Berg, David Reinhoudt

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (1) to yield the corresponding urea derivatives 5 was carried out in a continuous flow glass microfluidics chip. Real-time monitoring of the derivatization reactions was done by electrospray ionization mass spectrometry, making use of a recently reported modular chip-MS interface. Rate constants of 1.5 × 104, 5.2 × 104, and 2.4 × 104 M-1 min-1 were determined for 2, 3, and 4, respectively. Using macroscale batch conditions, the rate constants are 3-4 times lower. The faster on-chip kinetics is attributed to the more efficient molecular diffusion in the micrometer-sized channel.
Original languageEnglish
Pages (from-to)6852-6856
Number of pages5
JournalAnalytical chemistry
Volume77
Issue number21
DOIs
Publication statusPublished - 2005

Keywords

  • EWI-19276
  • IR-53016
  • METIS-225122

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