TY - JOUR
T1 - Chiral separation by enantioselective liquid-liquid extraction
AU - Schuur, Boelo
AU - Verkuijl, Bastiaan J.V.
AU - Minnaard, Adriaan J.
AU - De Vries, Johannes G.
AU - Heeres, Hero J.
AU - Feringa, Ben L.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and chemical engineers in the fields of fine chemicals, pharmaceuticals, agrochemicals, fragrances and foods. In this review the principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, starting with an introduction on the principles of enantioselective liquid-liquid extraction including host-guest chemistry, extraction and phase transfer mechanisms, and multistage liquid-liquid extraction processing. Then the literature on enantioselective liquid-liquid extraction systems is reviewed, structured on extractant classes. The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
AB - The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and chemical engineers in the fields of fine chemicals, pharmaceuticals, agrochemicals, fragrances and foods. In this review the principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, starting with an introduction on the principles of enantioselective liquid-liquid extraction including host-guest chemistry, extraction and phase transfer mechanisms, and multistage liquid-liquid extraction processing. Then the literature on enantioselective liquid-liquid extraction systems is reviewed, structured on extractant classes. The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
UR - http://www.scopus.com/inward/record.url?scp=78650110995&partnerID=8YFLogxK
U2 - 10.1039/c0ob00610f
DO - 10.1039/c0ob00610f
M3 - Article
C2 - 21107491
AN - SCOPUS:78650110995
SN - 1477-0520
VL - 9
SP - 36
EP - 51
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 1
ER -