Chiral separation by enantioselective liquid-liquid extraction

Boelo Schuur, Bastiaan J.V. Verkuijl, Adriaan J. Minnaard, Johannes G. De Vries*, Hero J. Heeres*, Ben L. Feringa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

172 Citations (Scopus)


The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and chemical engineers in the fields of fine chemicals, pharmaceuticals, agrochemicals, fragrances and foods. In this review the principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, starting with an introduction on the principles of enantioselective liquid-liquid extraction including host-guest chemistry, extraction and phase transfer mechanisms, and multistage liquid-liquid extraction processing. Then the literature on enantioselective liquid-liquid extraction systems is reviewed, structured on extractant classes. The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.

Original languageEnglish
Pages (from-to)36-51
Number of pages16
JournalOrganic and Biomolecular Chemistry
Issue number1
Publication statusPublished - 1 Jan 2011
Externally publishedYes


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