Chiral separation of amino-alcohols and amines by fractional reactive extraction

M. Steensma

    Research output: ThesisPhD Thesis - Research UT, graduation UT

    333 Downloads (Pure)


    In this thesis, fractional reactive extraction (FREX) is proposed and evaluated as alternative industrial separation technique. In FREX, an enantioselective extractant is applied as chiral selector. The process is versatile if the same extractant can be used with a good selectivity and capacity for a number of different substances from the same chemical class. Both enantiomers can be obtained at the desired purity by application of the fractional extraction scheme. Fractional reactive extraction combines in a liquid process flexibility with lower cost per chiral recognition site and high volumetric capacity. Despite its potential advantages over existing separation techniques, FREX is currently not applied on industrial scale because of a lack of versatile enantioselective extractants and a too low productivity. This thesis is therefore focused on identification of enantioselective extractants, improvement of productivity and technology development.
    Original languageUndefined
    Awarding Institution
    • University of Twente
    • de Haan, A.B., Supervisor
    • Kuipers, N.J.M., Co-Supervisor
    Award date27 Apr 2005
    Place of PublicationEnschede
    Print ISBNs9789090193137
    Publication statusPublished - 2005


    • IR-50749

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