TY - JOUR
T1 - Chiral separation of substituted phenylalanine analogues using chiral palladium phosphine complexes with enantioselective liquid-liquid extraction
AU - Verkuijl, Bastiaan J.V.
AU - Schuur, Boelo
AU - Minnaard, Adriaan J.
AU - De Vries, Johannes G.
AU - Feringa, Ben L.
PY - 2010/6/28
Y1 - 2010/6/28
N2 - Chiral palladium phosphine complexes have been employed in the chiral separation of amino acids and phenylalanine analogues in particular. The use of (S)-xylyl-BINAP as a ligand for the palladium complex in enantioselective liquid-liquid extraction allowed the separation of the phenylalanine analogues with the highest operational selectivity reported to date. 31P NMR, FTIR, FIR, UV-Vis, CD and Raman spectroscopy methods have been applied to gain insight into the binding mechanism of the amino acid substrates with the chiral palladium phosphine complexes. A complexation in a bidentate fashion is proposed.
AB - Chiral palladium phosphine complexes have been employed in the chiral separation of amino acids and phenylalanine analogues in particular. The use of (S)-xylyl-BINAP as a ligand for the palladium complex in enantioselective liquid-liquid extraction allowed the separation of the phenylalanine analogues with the highest operational selectivity reported to date. 31P NMR, FTIR, FIR, UV-Vis, CD and Raman spectroscopy methods have been applied to gain insight into the binding mechanism of the amino acid substrates with the chiral palladium phosphine complexes. A complexation in a bidentate fashion is proposed.
UR - http://www.scopus.com/inward/record.url?scp=77953791570&partnerID=8YFLogxK
U2 - 10.1039/b924749a
DO - 10.1039/b924749a
M3 - Article
C2 - 20480071
AN - SCOPUS:77953791570
SN - 1477-0520
VL - 8
SP - 3045
EP - 3054
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 13
ER -