Chiral Separations

B. Schuur*, A. B. de Haan, M. Kaspereit, M. Leeman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

3 Citations (Scopus)

Abstract

The most abundantly used route toward enantiopure chemical and biological products is through chiral separation of racemates. Several methods are available, of which crystallization is most used in industry, and chromatography is the most common analytical technique. The frequent use of crystallization in industrial applications is because of the relative cheapness of the technology and its maturity. Chiral chromatography is also a mature technology and very broadly applicable. Probably any racemate can be separated by means of chromatography, for which reason it is the most commonly applied technique for analytical purposes. Because it might be difficult to find a crystallizing agent, and because chromatography is expensive on large scale, several other techniques such as electrophoresis, liquid-liquid extraction, membrane-assisted separations, inclusion distillation, and inclusion precipitation have been developed. All these technologies are covered in this article.

Original languageEnglish
Title of host publicationEngineering Fundamentals of Biotechnology
PublisherElsevier Inc.
Chapter2.52
Pages737-751
Number of pages15
Volume2
ISBN (Electronic)9780080885049
ISBN (Print)9780444533524
DOIs
Publication statusPublished - 9 Sep 2011
Externally publishedYes

Keywords

  • Capillary electrophoresis
  • Chiral resolution
  • Chromatography
  • Crystallization
  • Inclusion complexation
  • Liquid-liquid extraction
  • Membrane separations

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