Chirurgische decompressie bij het ruimte-innemende herseninfarct; aanmelding voor een gerandomiseerde trial

J. Hofmeijer; H. B. Van Der Worp; G. J. Amelink; A. Algra; J. Van Gijn; L. J. Kappelle

Chirurgische decompressie bij het ruimte-innemende herseninfarct; aanmelding voor een gerandomiseerde trial

Translated title of the contribution: Surgical decompression in space-occupying cerebral infarct; notification of a randomised trial

J. Hofmeijer^*
, H. B. Van Der Worp
, G. J. Amelink
, A. Algra
, J. Van Gijn
, L. J. Kappelle

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

5 Citations (Scopus)

Abstract

Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite intensive conservative treatment, the case fatality rate may be as high as 80%, and most survivors are left severely disabled. Non-randomised studies suggest that decompressive surgery substantially reduces mortality and improves the functional outcome of survivors. The 'Hemicraniectomy after middle cerebral artery infarction with life-threatening edema trial' (HAMLET) is a newly-conceived randomised multi-centre clinical trial that compares the efficacy of decompressive surgery to improve functional outcome with that of conservative treatment in patients with space-occupying supratentorial infarction.

Translated title of the contribution	Surgical decompression in space-occupying cerebral infarct; notification of a randomised trial
Original language	Dutch
Pages (from-to)	2594-2596
Number of pages	3
Journal	Nederlands tijdschrift voor geneeskunde
Volume	147
Issue number	52
Publication status	Published - 27 Dec 2003
Externally published	Yes

Keywords

n/a OA procedure

Cite this

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title = "Chirurgische decompressie bij het ruimte-innemende herseninfarct; aanmelding voor een gerandomiseerde trial",

abstract = "Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite intensive conservative treatment, the case fatality rate may be as high as 80\%, and most survivors are left severely disabled. Non-randomised studies suggest that decompressive surgery substantially reduces mortality and improves the functional outcome of survivors. The 'Hemicraniectomy after middle cerebral artery infarction with life-threatening edema trial' (HAMLET) is a newly-conceived randomised multi-centre clinical trial that compares the efficacy of decompressive surgery to improve functional outcome with that of conservative treatment in patients with space-occupying supratentorial infarction.",

keywords = "n/a OA procedure",

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T1 - Chirurgische decompressie bij het ruimte-innemende herseninfarct; aanmelding voor een gerandomiseerde trial

AU - Hofmeijer, J.

AU - Van Der Worp, H. B.

AU - Amelink, G. J.

AU - Algra, A.

AU - Van Gijn, J.

AU - Kappelle, L. J.

PY - 2003/12/27

Y1 - 2003/12/27

N2 - Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite intensive conservative treatment, the case fatality rate may be as high as 80%, and most survivors are left severely disabled. Non-randomised studies suggest that decompressive surgery substantially reduces mortality and improves the functional outcome of survivors. The 'Hemicraniectomy after middle cerebral artery infarction with life-threatening edema trial' (HAMLET) is a newly-conceived randomised multi-centre clinical trial that compares the efficacy of decompressive surgery to improve functional outcome with that of conservative treatment in patients with space-occupying supratentorial infarction.

AB - Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite intensive conservative treatment, the case fatality rate may be as high as 80%, and most survivors are left severely disabled. Non-randomised studies suggest that decompressive surgery substantially reduces mortality and improves the functional outcome of survivors. The 'Hemicraniectomy after middle cerebral artery infarction with life-threatening edema trial' (HAMLET) is a newly-conceived randomised multi-centre clinical trial that compares the efficacy of decompressive surgery to improve functional outcome with that of conservative treatment in patients with space-occupying supratentorial infarction.

KW - n/a OA procedure

UR - https://www.scopus.com/pages/publications/0347755064

M3 - Review article

C2 - 14723030

AN - SCOPUS:0347755064

SN - 0028-2162

VL - 147

SP - 2594

EP - 2596

JO - Nederlands tijdschrift voor geneeskunde

JF - Nederlands tijdschrift voor geneeskunde

IS - 52

ER -

Chirurgische decompressie bij het ruimte-innemende herseninfarct; aanmelding voor een gerandomiseerde trial

Abstract

Keywords

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