Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels

Research output: Contribution to journalArticleAcademicpeer-review

95 Citations (Scopus)
1 Downloads (Pure)

Abstract

In this study, injectable hydrogels were prepared by horseradish peroxidase-mediated co-crosslinking of dextran–tyramine (Dex–TA) and heparin–tyramine (Hep–TA) conjugates and used as scaffolds for cartilage tissue engineering. The swelling and mechanical properties of these hydrogels can be easily controlled by the Dex–TA/Hep–TA weight ratio. When chondrocytes were incorporated in these gels, cell viability and proliferation were highest for gels with a 50/50 weight ratio of Dex–TA/Hep–TA. Moreover, these hydrogels induced an enhanced production of chondroitin sulfate and a more abundant presence of collagen as compared to Dex–TA hydrogels. The results indicate that injectable Dex–TA/Hep–TA hydrogels are promising scaffolds for cartilage regeneration.
Original languageEnglish
Pages (from-to)186-195
JournalJournal of controlled release
Volume152
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Hydrogel
  • Dextran
  • Heparin
  • METIS-283833
  • IR-80641
  • Chondrogenesis

Fingerprint Dive into the research topics of 'Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels'. Together they form a unique fingerprint.

Cite this