Chromatin Structure in Bands and Interbands of Polytene Chromosomes Imaged by Atomic Force Microscopy

C.J. de Grauw, A. Avogadro, D.J. van den Heuvel, K.O. van der Werf, C. Otto, Y. Kraan, N.F. van Hulst, J. Greve

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Polytene chromosomes from Drosophila melanogaster, observed from squash preparations, and chromosomes from Chironomus thummi thummi, investigated under physiological conditions, are imaged using an Atomic Force Microscope. Various chromatin fiber structures can be observed with high detail in fixed chromosomes and correspond to structures which are also observed in chromosomes of diploid cells. Unfixed chromosomes can be imaged in buffer and show less fiber-like details because of the inherent soft nature of the chromatin material.
Original languageEnglish
Pages (from-to)2-8
Number of pages7
JournalJournal of structural biology
Volume121
Issue number1
DOIs
Publication statusPublished - 1998

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