Classifying Raman Spectra of Extracellular Vesicles based on Convolutional Neural Networks for Prostate Cancer Detection

Wooje Lee, Aufried T.M. Lenferink, Cornelis Otto, H.L. Offerhaus*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
25 Downloads (Pure)

Abstract

Since early 2000s, machine learning algorithms have been widely used in many research and industrial fields, most prominently in computer vison. Lately, many fields of study have tried to use these automated methods, and there are several reports from the field of spectroscopy. In this study, we demonstrate a classification model based on machine learning to classify Raman spectra. We obtained Raman spectra from extracellular vesicles (EVs) to find tumor derived EVs. The convolutional neural network (CNN) was trained on preprocessed Raman data and raw Raman data. We compare the result from CNN with results from principal component analysis that is widely used among in spectroscopy. The new model classifies EVs with an accuracy of >90%. Moreover, the new model based on CNN is also suitable for classifying the raw Raman data directly without preprocessing with a minimum accuracy of 93%.
Original languageEnglish
Pages (from-to)293-300
Number of pages8
JournalJournal of raman spectroscopy
Volume51
Issue number2
Early online date7 Nov 2019
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • UT-Hybrid-D
  • Convolutional Neural Network
  • Extracellular vesicles
  • Machine Learning
  • Raman Spectroscopy
  • Cancer Biomarker
  • Cancer biomarker
  • extracellular vesicles
  • convolutional neural network
  • Raman spectroscopy
  • machine learning

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