Clickable poly-l-lysine for the formation of biorecognition surfaces

Daniele Di Iorio, Almudena Marti, Sander Koeman, Jurriaan Huskens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
110 Downloads (Pure)


Biomolecules are immobilized onto surfaces employing the fast and stable adsorption of poly-l-lysine (PLL) polymers and the versatile copper-free click chemistry reactions. This method provides the combined advantages of versatile surface adsorption with density control using polyelectrolytes and of the covalent and orthogonal immobilization of biomolecules with higher reaction rates and improved yields of click chemistry. Using DNA attachment as a proof of concept, control over the DNA probe density and applicability in electrochemical detection are presented.

Original languageEnglish
Pages (from-to)35608-35613
Number of pages6
JournalRSC advances
Issue number61
Publication statusPublished - 4 Nov 2019


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