Clinical applications of laser speckle contrast imaging: a review

Wido Heeman, Wiendelt Steenbergen, Gooitzen van Dam, E. Christiaan Boerma

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Abstract

When a biological tissue is illuminated with coherent light, an interference pattern will be formed at the detector, the so-called speckle pattern. Laser speckle contrast imaging (LSCI) is a technique based on the dynamic change in this backscattered light as a result of interaction with red blood cells. It can be used to visualize perfusion in various tissues and, even though this technique has been extensively described in the literature, the actual clinical implementation lags behind. We provide an overview of LSCI as a tool to image tissue perfusion. We present a brief introduction to the theory, review clinical studies from various medical fields, and discuss current limitations impeding clinical acceptance.

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Original languageEnglish
Article number080901
Pages (from-to)1-11
Number of pages11
JournalJournal of biomedical optics
Volume24
Issue number8
DOIs
Publication statusPublished - 1 Aug 2019

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Speckle
Tissue
Imaging techniques
Lasers
lasers
Light interference
coherent light
speckle patterns
erythrocytes
acceptability
Blood
time lag
Cells
Detectors
interference
detectors
interactions

Keywords

  • burn wounds
  • cerebral blood flow
  • laser speckle contrast imaging
  • microcirculation
  • retinal perfusion

Cite this

Heeman, Wido ; Steenbergen, Wiendelt ; van Dam, Gooitzen ; Boerma, E. Christiaan. / Clinical applications of laser speckle contrast imaging : a review. In: Journal of biomedical optics. 2019 ; Vol. 24, No. 8. pp. 1-11.
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Clinical applications of laser speckle contrast imaging : a review. / Heeman, Wido; Steenbergen, Wiendelt; van Dam, Gooitzen; Boerma, E. Christiaan.

In: Journal of biomedical optics, Vol. 24, No. 8, 080901, 01.08.2019, p. 1-11.

Research output: Contribution to journalArticleAcademicpeer-review

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