Clinical applications of laser speckle contrast imaging: a review

Wido Heeman, Wiendelt Steenbergen, Gooitzen van Dam, E. Christiaan Boerma

Research output: Contribution to journalReview articleAcademicpeer-review

209 Citations (Scopus)
297 Downloads (Pure)


When a biological tissue is illuminated with coherent light, an interference pattern will be formed at the detector, the so-called speckle pattern. Laser speckle contrast imaging (LSCI) is a technique based on the dynamic change in this backscattered light as a result of interaction with red blood cells. It can be used to visualize perfusion in various tissues and, even though this technique has been extensively described in the literature, the actual clinical implementation lags behind. We provide an overview of LSCI as a tool to image tissue perfusion. We present a brief introduction to the theory, review clinical studies from various medical fields, and discuss current limitations impeding clinical acceptance.

Original languageEnglish
Article number080901
Pages (from-to)1-11
Number of pages11
JournalJournal of biomedical optics
Issue number8
Publication statusPublished - 1 Aug 2019


  • burn wounds
  • cerebral blood flow
  • laser speckle contrast imaging
  • microcirculation
  • retinal perfusion


Dive into the research topics of 'Clinical applications of laser speckle contrast imaging: a review'. Together they form a unique fingerprint.

Cite this