Clinical evaluation of radio-labelled bleomycin for tumor detection

J.J. Rasker, H. Beekhuis, M.A.P.C. van de Poll, A. Versluis, H. Jurjens, M.G. Woldring

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Abstract

Investigations with bleomycin labelled with radionuclides other than 57Co in patients with cancer and in tumor-bearing animals are described. In patients 57Co-bleo appears to be a better tumor-seeking radiopharmaceutical than 111In-bleo, 99mTc-bleo or 197Hg-bleo. This can be explained by a higher stability in vivo and a better tumor-seeking property of 57Co-bleo and less disturbing activity in the cardiac pool and in bone and other normal tissues when assessing the scintigram. Results with 111In-bleo labelled in acidic solution are not essentially different from those with 111In-bleo labelled in neutral solution. Results of 197Hg-bleo are almost identical with those of 197HgCl2 regarding the tumor-seeking effect as well as the distribution in normal tissues and organs. Probably the complex of 197Hg to bleomycin is not stable in vivo. The superiority of 57Co-bleo over 99mTc-bleo and also over 67Cu-bleo is confirmed by experiments on tumor bearing animals. We conclude that the indication for use of bleomycin as a tumor-seeking pharmaceutical labelled with 111In, 99mTc, 197Hg or 67Cu seems to be very limited.

Original languageEnglish
Pages (from-to)238-248
Number of pages11
JournalNuklear Medizin - Isotope In Medizin und Biologie
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Dec 1978
Externally publishedYes

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    Rasker, J. J., Beekhuis, H., van de Poll, M. A. P. C., Versluis, A., Jurjens, H., & Woldring, M. G. (1978). Clinical evaluation of radio-labelled bleomycin for tumor detection. Nuklear Medizin - Isotope In Medizin und Biologie, 17(6), 238-248. https://doi.org/10.1055/s-0037-1620700