Clinical outcome after bleeding events following coronary stenting in patients with and without comorbid peripheral arterial disease

Tineke H. Pinxterhuis, Eline H. Ploumen, Marlies M. Kok, Carl E. Schotborgh, Rutger L. Anthonio, Ariel Roguin, Peter W. Danse, Edouard Benit, Adel Aminian, Marc Hartmann, Gerard C.M. Linssen, Robert H. Geelkerken, Carine J.M. Doggen, Clemens von Birgelen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Patients undergoing percutaneous coronary intervention (PCI) may experience bleeding events. Bleeding risk is increased in patients with comorbid peripheral arterial disease (PADs). To evaluate whether PCI patients with PADs have worse outcome after bleeding, we assessed pooled patient-level data of 5,989 randomized all-comer trial participants and identified those who had a bleeding (BIO-RESORT:NCT01674803, BIONYX:NCT02508714). Major adverse cardiac events (MACE) and mortality were assessed from bleeding until 3 years after PCI. Of all 313 PCI patients with bleeding events, patients with PADs (n = 34, 10.9%) were older and had more complex lesions than those without PADs (n = 279, 89.1%). In patients with PADs, bleeding occurred more often during the first year after PCI (79.4% vs. 57.3%, p = 0.013). The proportion of major bleeding, and the severity and location of bleeding were similar between both groups. Multivariate analysis found no statistically significant between-group difference in MACE (43.1% vs. 34.7%, p = 0.53; adj.HR:0.86, 95%CI 0.45–1.63, p = 0.64) and mortality (33.5% vs. 22.3%, p = 0.12; adj.HR:1.45, 95%CI 0.73–2.91, p = 0.29). Bleeding occurred significantly more often during the first year after PCI in all-comer patients with concomitant PADs than in those without PADs, while we observed no significant between-group difference in bleeding severity and location, and the risk of adverse events after bleeding.

Original languageEnglish
Article numbere001004
JournalCardiovascular Intervention and Therapeutics
DOIs
Publication statusE-pub ahead of print/First online - 19 Dec 2024

Keywords

  • 2025 OA procedure
  • Coronary artery disease
  • Drug-eluting stents
  • Percutaneous coronary intervention
  • Peripheral arterial disease
  • Bleeding

Fingerprint

Dive into the research topics of 'Clinical outcome after bleeding events following coronary stenting in patients with and without comorbid peripheral arterial disease'. Together they form a unique fingerprint.

Cite this