Clinical outcomes after percutaneous coronary intervention with the COMBO stent versus Resolute Integrity and PROMUS Element stents: A propensity-matched analysis

Deborah N. Kalkman, Marlies M. Kok, Liefke C. van der Heijden, Pier Woudstra, Marcel A.M. Beijk, Jan G.P. Tijssen, Clemens von Birgelen, Robbert J. de Winter

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Abstract

Aims: The COMBO stent combines sirolimus elution with an endothelial progenitor cell-capturing layer to promote early endothelialisation. There has not been a head-to-head comparison of this novel device with any other currently used drug-eluting stent (DES). We sought to compare clinical outcome at two years after COMBO stent placement with the Resolute Integrity or PROMUS Element stent in an all-comers cohort.

Methods and results: Patients from the REMEDEE registry (COMBO, n=1, 000) were matched with patients from the Dutch PEERS trial (PROMUS Element/Resolute Integrity, n=1, 811). Propensity score matching on 13 baseline characteristics was applied to create two balanced cohorts of patients treated with COMBO versus PROMUS Element/Resolute Integrity. Propensity score matching yielded 771 patient pairs, representing all-comers patients, with a median age of 65 years, 27% female and more than 50% of patients presenting with acute coronary syndrome. Target lesion failure (TLF), a composite of cardiac death, target vessel MI and any target lesion revascularisation, at two-year follow-up was 7.9% in COMBO and 6.4% in PROMUS Element/Resolute Integrity, HR 1.24 (95% CI: 0.85-1.81), p=0.26. Definite stent thrombosis (ST) was not significantly different between groups (0.8% vs. 0.9%, p=0.79).

Conclusions: In a propensity-matched analysis, the COMBO stent showed similar rates of TLF and ST at two-year follow-up compared to Resolute Integrity and PROMUS Element.

Original languageEnglish
Pages (from-to)1202-1209
Number of pages8
JournalEuroIntervention
Volume13
Issue number10
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Clinical research
  • Clinical trials
  • Coronary occlusion
  • Drug-eluting stent
  • Stent thrombosis

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