TY - JOUR
T1 - Clinical usefulness of drug-laboratory test interaction alerts
T2 - A multicentre survey
AU - van Balveren, Jasmijn A.
AU - Verboeket-Van de Venne, Wilhelmine P.H.G.
AU - Doggen, Carine J.M.
AU - Cornelissen, Anne S.
AU - Erdem-Eraslan, Lale
AU - de Graaf, Albert J.
AU - Krabbe, Johannes G.
AU - Musson, Ruben E.A.
AU - Oosterhuis, Wytze P.
AU - de Rijke, Yolanda B.
AU - van der Sijs, Heleen
AU - Tintu, Andrei N.
AU - Verheul, Rolf J.
AU - Hoedemakers, Rein M.J.
AU - Kusters, Ron
AU - on behalf of the Dutch Society for Clinical Chemistry and Laboratory Medicine and task group ‘SMILE’: Signaling Medication Interactions and Laboratory test Expert system
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Objectives: Knowledge of possible drug-laboratory test interactions (DLTIs) is important for the interpretation of laboratory test results. Failure to recognize these interactions may lead to misinterpretation, a delayed or erroneous diagnosis, or unnecessary extra diagnostic tests or therapy, which may harm patients. The aim of this multicentre survey was to evaluate the clinical value of DLTI alerts.Methods: A survey was designed with six predefined clinical cases selected from the clinical laboratory practice with a potential DLTI. Physicians from several departments, including internal medicine, cardiology, intensive care, surgery and geriatrics in six participating hospitals were recruited to fill in the survey. The survey addressed their knowledge of DLTIs, motivation to receive an alert and opinion on the potential influence on medical decision making.Results: A total of 210 physicians completed the survey. Of these respondents 93% had a positive attitude towards receiving DLTI alerts; however, the reported value differed per case and per respondent’s background. In each clinical case, medical decision making was influenced as a consequence of the reported DLTI message (ranging from 3 to 45% of respondents per case).Conclusions: In this multicentre survey, most physicians stated DLTI messages to be useful in laboratory test interpretation. Medical decision making was influenced by reporting DLTI alerts in each case. Alerts should be adjusted according to the needs and preferences of the receiving physicians.
AB - Objectives: Knowledge of possible drug-laboratory test interactions (DLTIs) is important for the interpretation of laboratory test results. Failure to recognize these interactions may lead to misinterpretation, a delayed or erroneous diagnosis, or unnecessary extra diagnostic tests or therapy, which may harm patients. The aim of this multicentre survey was to evaluate the clinical value of DLTI alerts.Methods: A survey was designed with six predefined clinical cases selected from the clinical laboratory practice with a potential DLTI. Physicians from several departments, including internal medicine, cardiology, intensive care, surgery and geriatrics in six participating hospitals were recruited to fill in the survey. The survey addressed their knowledge of DLTIs, motivation to receive an alert and opinion on the potential influence on medical decision making.Results: A total of 210 physicians completed the survey. Of these respondents 93% had a positive attitude towards receiving DLTI alerts; however, the reported value differed per case and per respondent’s background. In each clinical case, medical decision making was influenced as a consequence of the reported DLTI message (ranging from 3 to 45% of respondents per case).Conclusions: In this multicentre survey, most physicians stated DLTI messages to be useful in laboratory test interpretation. Medical decision making was influenced by reporting DLTI alerts in each case. Alerts should be adjusted according to the needs and preferences of the receiving physicians.
KW - (computerized) clinical decision support
KW - Clinical laboratory test
KW - Diagnostic error
KW - Drug-laboratory test interaction
KW - Patient safety
UR - http://www.scopus.com/inward/record.url?scp=85102101227&partnerID=8YFLogxK
U2 - 10.1515/cclm-2020-1770
DO - 10.1515/cclm-2020-1770
M3 - Article
AN - SCOPUS:85102101227
SN - 1434-6621
VL - 59
SP - 1239
EP - 1245
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 7
ER -