Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy

Mounir W.Z. Basalus, Marc J.K. Ankoné, K. Gert van Houwelingen, Frits H.A.F. de Man, Clemens von Birgelen

    Research output: Contribution to journalArticleAcademicpeer-review

    38 Downloads (Pure)

    Abstract

    AIMS: To classify and quantify post-expansion irregularities in durable polymer-based coatings of drug-eluting stents (DES).

    METHODS AND RESULTS: Taxus Liberté, Endeavor Sprint, Endeavor Resolute and Xience V DES (three samples of each) were explored by light microscopy and scanning electron microscopy (SEM) following expansion at 14 atm in water. Incidence and size of irregularities were measured during thorough quantitative examinations of a 360 SEM images. DES types examined showed a significant difference in the incidence of irregularities (p<0.0001; 6.6+/-4.2/image at 60-fold magnification) with typical patterns specific for each DES. All types showed areas with bare metal-aspects, but incidence, shape, and size differed largely: Sprint showed the largest areas. Cracks were only found in Sprint and Resolute, while wrinkles were seen exclusively in Taxus Liberté and Xience V (p<0.0001). The coating of each DES type showed some inhomogeneity of distribution, but the incidence differed (p<0.0001) and was least in Taxus Liberté, which, on the other hand, was the only DES that showed webbing with large bare-metal exposure.

    CONCLUSIONS: The incidence and size of various coating irregularities on different types of DES varied widely. These data may be considered in ongoing discussions on the differences between DES and may serve as reference to compare novel DES.

    Original languageEnglish
    Pages (from-to)157-165
    Number of pages9
    JournalEuroIntervention
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Drug-Eluting Stents
    Electron Scanning Microscopy
    Polymers
    Taxus
    Incidence
    Metals
    Microscopy
    Light
    Water

    Keywords

    • METIS-259911
    • Drug-eluting stent(s)
    • Percutaneous Coronary Intervention (PCI)
    • Polymer coating
    • Scanning Electron Microscopy (SEM)
    • Coronary artery disease

    Cite this

    Basalus, Mounir W.Z. ; Ankoné, Marc J.K. ; van Houwelingen, K. Gert ; de Man, Frits H.A.F. ; von Birgelen, Clemens. / Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy. In: EuroIntervention. 2009 ; Vol. 5, No. 1. pp. 157-165.
    @article{3ab54ca11b2b42e9b2b0c389c1ab7a5c,
    title = "Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy",
    abstract = "AIMS: To classify and quantify post-expansion irregularities in durable polymer-based coatings of drug-eluting stents (DES).METHODS AND RESULTS: Taxus Libert{\'e}, Endeavor Sprint, Endeavor Resolute and Xience V DES (three samples of each) were explored by light microscopy and scanning electron microscopy (SEM) following expansion at 14 atm in water. Incidence and size of irregularities were measured during thorough quantitative examinations of a 360 SEM images. DES types examined showed a significant difference in the incidence of irregularities (p<0.0001; 6.6+/-4.2/image at 60-fold magnification) with typical patterns specific for each DES. All types showed areas with bare metal-aspects, but incidence, shape, and size differed largely: Sprint showed the largest areas. Cracks were only found in Sprint and Resolute, while wrinkles were seen exclusively in Taxus Libert{\'e} and Xience V (p<0.0001). The coating of each DES type showed some inhomogeneity of distribution, but the incidence differed (p<0.0001) and was least in Taxus Libert{\'e}, which, on the other hand, was the only DES that showed webbing with large bare-metal exposure.CONCLUSIONS: The incidence and size of various coating irregularities on different types of DES varied widely. These data may be considered in ongoing discussions on the differences between DES and may serve as reference to compare novel DES.",
    keywords = "METIS-259911, Drug-eluting stent(s), Percutaneous Coronary Intervention (PCI), Polymer coating, Scanning Electron Microscopy (SEM), Coronary artery disease",
    author = "Basalus, {Mounir W.Z.} and Ankon{\'e}, {Marc J.K.} and {van Houwelingen}, {K. Gert} and {de Man}, {Frits H.A.F.} and {von Birgelen}, Clemens",
    year = "2009",
    doi = "10.4244/EIJV5I1A24",
    language = "English",
    volume = "5",
    pages = "157--165",
    journal = "EuroIntervention",
    issn = "1774-024X",
    publisher = "EuroPCR",
    number = "1",

    }

    Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy. / Basalus, Mounir W.Z.; Ankoné, Marc J.K.; van Houwelingen, K. Gert; de Man, Frits H.A.F.; von Birgelen, Clemens.

    In: EuroIntervention, Vol. 5, No. 1, 2009, p. 157-165.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy

    AU - Basalus, Mounir W.Z.

    AU - Ankoné, Marc J.K.

    AU - van Houwelingen, K. Gert

    AU - de Man, Frits H.A.F.

    AU - von Birgelen, Clemens

    PY - 2009

    Y1 - 2009

    N2 - AIMS: To classify and quantify post-expansion irregularities in durable polymer-based coatings of drug-eluting stents (DES).METHODS AND RESULTS: Taxus Liberté, Endeavor Sprint, Endeavor Resolute and Xience V DES (three samples of each) were explored by light microscopy and scanning electron microscopy (SEM) following expansion at 14 atm in water. Incidence and size of irregularities were measured during thorough quantitative examinations of a 360 SEM images. DES types examined showed a significant difference in the incidence of irregularities (p<0.0001; 6.6+/-4.2/image at 60-fold magnification) with typical patterns specific for each DES. All types showed areas with bare metal-aspects, but incidence, shape, and size differed largely: Sprint showed the largest areas. Cracks were only found in Sprint and Resolute, while wrinkles were seen exclusively in Taxus Liberté and Xience V (p<0.0001). The coating of each DES type showed some inhomogeneity of distribution, but the incidence differed (p<0.0001) and was least in Taxus Liberté, which, on the other hand, was the only DES that showed webbing with large bare-metal exposure.CONCLUSIONS: The incidence and size of various coating irregularities on different types of DES varied widely. These data may be considered in ongoing discussions on the differences between DES and may serve as reference to compare novel DES.

    AB - AIMS: To classify and quantify post-expansion irregularities in durable polymer-based coatings of drug-eluting stents (DES).METHODS AND RESULTS: Taxus Liberté, Endeavor Sprint, Endeavor Resolute and Xience V DES (three samples of each) were explored by light microscopy and scanning electron microscopy (SEM) following expansion at 14 atm in water. Incidence and size of irregularities were measured during thorough quantitative examinations of a 360 SEM images. DES types examined showed a significant difference in the incidence of irregularities (p<0.0001; 6.6+/-4.2/image at 60-fold magnification) with typical patterns specific for each DES. All types showed areas with bare metal-aspects, but incidence, shape, and size differed largely: Sprint showed the largest areas. Cracks were only found in Sprint and Resolute, while wrinkles were seen exclusively in Taxus Liberté and Xience V (p<0.0001). The coating of each DES type showed some inhomogeneity of distribution, but the incidence differed (p<0.0001) and was least in Taxus Liberté, which, on the other hand, was the only DES that showed webbing with large bare-metal exposure.CONCLUSIONS: The incidence and size of various coating irregularities on different types of DES varied widely. These data may be considered in ongoing discussions on the differences between DES and may serve as reference to compare novel DES.

    KW - METIS-259911

    KW - Drug-eluting stent(s)

    KW - Percutaneous Coronary Intervention (PCI)

    KW - Polymer coating

    KW - Scanning Electron Microscopy (SEM)

    KW - Coronary artery disease

    U2 - 10.4244/EIJV5I1A24

    DO - 10.4244/EIJV5I1A24

    M3 - Article

    VL - 5

    SP - 157

    EP - 165

    JO - EuroIntervention

    JF - EuroIntervention

    SN - 1774-024X

    IS - 1

    ER -