Coating Membranes for a Sorbent-Based Artificial Liver: Adsorption Characteristics

Henk W.M. de Koning; Rob A.F.M. Chamuleau; Adriaan Bantjes

doi:10.1111/j.1525-1594.1982.tb01673.x

Coating Membranes for a Sorbent-Based Artificial Liver: Adsorption Characteristics

Henk W.M. de Koning, Rob A.F.M. Chamuleau, Adriaan Bantjes

Research output: Contribution to journal › Article › Academic

6 Citations (Scopus)

148 Downloads (Pure)

Abstract

Techniques are described for the coating of sorbents to be used in an artificial liver support system based on mixed sor‐bent bed hemoperfusion. Activated charcoal has been coated with cellulose acetate (CA) by solvent evaporation. With Amberlite XAD‐4, the Wurster technique was used for coating with CA. XAD‐4 has also been coated with a synthetic poly‐electrolyte with anticoagulant activity by adsorption and fixation by gamma radiation‐induced crosslinking. Activated charcoal, XAD‐4, and a cation exchange resin, all in powdered form, were encapsulated in agarose gel beads. Adsorption characteristics onto the sorbents are described. The results are in agreement with a theoretical model presented. In general, adsorption onto XAD‐4 is limited by film diffusion. With activated charcoal, pore diffusion limitation is generally observed. Blood compatibility is improved by coating.

Original language	English
Pages (from-to)	280-287
Journal	Artificial organs
Volume	6
Issue number	3
DOIs	https://doi.org/10.1111/j.1525-1594.1982.tb01673.x
Publication status	Published - 1982

Keywords

Blood compatibility
Sorbents
IR-70661
Adsorption kinetics theory and practice
Coatings

Access to Document

10.1111/j.1525-1594.1982.tb01673.x

Koning82coatingFinal published version, 704 KB

Cite this

@article{b2e36371cfc04ebab97277edb48f2643,

title = "Coating Membranes for a Sorbent-Based Artificial Liver: Adsorption Characteristics",

abstract = "Techniques are described for the coating of sorbents to be used in an artificial liver support system based on mixed sor‐bent bed hemoperfusion. Activated charcoal has been coated with cellulose acetate (CA) by solvent evaporation. With Amberlite XAD‐4, the Wurster technique was used for coating with CA. XAD‐4 has also been coated with a synthetic poly‐electrolyte with anticoagulant activity by adsorption and fixation by gamma radiation‐induced crosslinking. Activated charcoal, XAD‐4, and a cation exchange resin, all in powdered form, were encapsulated in agarose gel beads. Adsorption characteristics onto the sorbents are described. The results are in agreement with a theoretical model presented. In general, adsorption onto XAD‐4 is limited by film diffusion. With activated charcoal, pore diffusion limitation is generally observed. Blood compatibility is improved by coating.",

keywords = "Blood compatibility, Sorbents, IR-70661, Adsorption kinetics theory and practice, Coatings",

author = "{de Koning}, {Henk W.M.} and Chamuleau, {Rob A.F.M.} and Adriaan Bantjes",

year = "1982",

doi = "10.1111/j.1525-1594.1982.tb01673.x",

language = "English",

volume = "6",

pages = "280--287",

journal = "Artificial organs",

issn = "0160-564X",

publisher = "Wiley",

number = "3",

}

TY - JOUR

T1 - Coating Membranes for a Sorbent-Based Artificial Liver

T2 - Adsorption Characteristics

AU - de Koning, Henk W.M.

AU - Chamuleau, Rob A.F.M.

AU - Bantjes, Adriaan

PY - 1982

Y1 - 1982

N2 - Techniques are described for the coating of sorbents to be used in an artificial liver support system based on mixed sor‐bent bed hemoperfusion. Activated charcoal has been coated with cellulose acetate (CA) by solvent evaporation. With Amberlite XAD‐4, the Wurster technique was used for coating with CA. XAD‐4 has also been coated with a synthetic poly‐electrolyte with anticoagulant activity by adsorption and fixation by gamma radiation‐induced crosslinking. Activated charcoal, XAD‐4, and a cation exchange resin, all in powdered form, were encapsulated in agarose gel beads. Adsorption characteristics onto the sorbents are described. The results are in agreement with a theoretical model presented. In general, adsorption onto XAD‐4 is limited by film diffusion. With activated charcoal, pore diffusion limitation is generally observed. Blood compatibility is improved by coating.

AB - Techniques are described for the coating of sorbents to be used in an artificial liver support system based on mixed sor‐bent bed hemoperfusion. Activated charcoal has been coated with cellulose acetate (CA) by solvent evaporation. With Amberlite XAD‐4, the Wurster technique was used for coating with CA. XAD‐4 has also been coated with a synthetic poly‐electrolyte with anticoagulant activity by adsorption and fixation by gamma radiation‐induced crosslinking. Activated charcoal, XAD‐4, and a cation exchange resin, all in powdered form, were encapsulated in agarose gel beads. Adsorption characteristics onto the sorbents are described. The results are in agreement with a theoretical model presented. In general, adsorption onto XAD‐4 is limited by film diffusion. With activated charcoal, pore diffusion limitation is generally observed. Blood compatibility is improved by coating.

KW - Blood compatibility

KW - Sorbents

KW - IR-70661

KW - Adsorption kinetics theory and practice

KW - Coatings

U2 - 10.1111/j.1525-1594.1982.tb01673.x

DO - 10.1111/j.1525-1594.1982.tb01673.x

M3 - Article

SN - 0160-564X

VL - 6

SP - 280

EP - 287

JO - Artificial organs

JF - Artificial organs

IS - 3

ER -

Coating Membranes for a Sorbent-Based Artificial Liver: Adsorption Characteristics

Abstract

Keywords

Access to Document

Fingerprint

Cite this