TY - JOUR
T1 - Cognition in MS correlates with resting-state oscillatory brain activity
T2 - An explorative MEG source-space study
AU - van der Meer, M.L.
AU - Tewarie, P.
AU - Schoonheim, M.M.
AU - Douw, L.
AU - Barkhof, F.
AU - Polman, C.H.
AU - Stam, C.J.
AU - Hillebrand, A.
N1 - Funding Information:
This study and the MS center Amsterdam was sponsored by the Dutch MS research foundation , grant numbers 08-650 and 09-358d . The study was additionally supported by the ‘Stichting tot bevordering wetenschappelijk KNF onderzoek’ (Dutch Foundation for Clinical Neurophsyiology research) . L. Douw was sponsored by an NWO Rubicon grant (no. 825.11.002 ) and an NIH grant (no. 5R01NS069696-02 ). We thank Judith Sonder for assessing neuropsychological tests and Libertje Bosma, Madeleine Sombekke, Alexandra Seewann and Eva Strijbis for assessing the EDSS for all patients. Appendix A1 1 Rectus_L 40 Rectus_R 2 Olfactory_L 41 Olfactory_R 3 Frontal_Sup_Orb_L 42 Frontal_Sup_Orb_R 4 Frontal_Med_Orb_L 43 Frontal_Med_Orb_R 5 Frontal_Mid_Orb_L 44 Frontal_Mid_Orb_R 6 Frontal_Inf_Orb_L 45 Frontal_Inf_Orb_R 7 Frontal_Sup_L 46 Frontal_Sup_R 8 Frontal_Mid_L 47 Frontal_Mid_R 9 Frontal_Inf_Oper_L 48 Frontal_Inf_Oper_R 10 Frontal_Inf_Tri_L 49 Frontal_Inf_Tri_R 11 Frontal_Sup_Medial_L 50 Frontal_Sup_Medial_R 12 Supp_Motor_Area_L 51 Supp_Motor_Area_R 13 Paracentral_Lobule_L 52 Paracentral_Lobule_R 14 Precentral_L 53 Precentral_R 15 Rolandic_Oper_L 54 Rolandic_Oper_R 16 Postcentral_L 55 Postcentral_R 17 Parietal_Sup_L 56 Parietal_Sup_R 18 Parietal_Inf_L 57 Parietal_Inf_R 19 SupraMarginal_L 58 SupraMarginal_R 20 Angular_L 59 Angular_R 21 Precuneus_L 60 Precuneus_R 22 Occipital_Sup_L 61 Occipital_Sup_R 23 Occipital_Mid_L 62 Occipital_Mid_R 24 Occipital_Inf_L 63 Occipital_Inf_R 25 Calcarine_L 64 Calcarine_R 26 Cuneus_L 65 Cuneus_R 27 Lingual_L 66 Lingual_R 28 Fusiform_L 67 Fusiform_R 29 Heschl_L 68 Heschl_R 30 Temporal_Sup_L 69 Temporal_Sup_R 31 Temporal_Mid_L 70 Temporal_Mid_R 32 Temporal_Inf_L 71 Temporal_Inf_R 33 Temporal_Pole_Sup_L 72 Temporal_Pole_Sup_R 34 Temporal_Pole_Mid_L 73 Temporal_Pole_Mid_R 35 ParaHippocampal_L 74 ParaHippocampal_R 36 Cingulum_Ant_L 75 Cingulum_Ant_R 37 Cingulum_Mid_L 76 Cingulum_Mid_R 38 Cingulum_Post_L 77 Cingulum_Post_R 39 Insula_L 78 Insula_R
PY - 2013
Y1 - 2013
N2 - Clinical and cognitive dysfunction in Multiple Sclerosis (MS) is insufficiently explained by structural damage as identified by traditional magnetic resonance imaging (MRI) of the brain, indicating the need for reliable functional measures in MS. We investigated whether altered resting-state oscillatory power could be related to clinical and cognitive dysfunction in MS. MEG recordings were acquired using a 151-channel whole-head MEG system from 21 relapsing remitting MS patients and 17 healthy age-, gender-, and education-matched controls, using an eyes-closed no-task condition. Relative spectral power was estimated for 78 regions of interest, using an atlas-based beamforming approach, for classical frequency bands; delta, theta, alpha1, alpha2, beta and gamma. These cortical power estimates were compared between groups by means of permutation analysis and correlated with clinical disability (Expanded Disability Status Scale: EDSS), cognitive performance and MRI measures of atrophy and lesion load. Patients showed increased power in the alpha1 band and decreased power in the alpha2 band, compared to controls, mainly in occipital, parietal and temporal areas, confirmed by a lower alpha peak-frequency. Increased power in the alpha1 band was associated with worse overall cognition and especially with information processing speed. Our quantitative relative power analysis of MEG recordings showed abnormalities in oscillatory brain dynamics in MS patients in the alpha band. By applying source-space analyses, this study provides a detailed topographical view of abnormal brain activity in MS patients, especially localized to occipital areas. Interestingly, poor cognitive performance was related to high resting-state alpha1 power indicating that changes in oscillatory activity might be of value as an objective measure of disease burden in MS patients.
AB - Clinical and cognitive dysfunction in Multiple Sclerosis (MS) is insufficiently explained by structural damage as identified by traditional magnetic resonance imaging (MRI) of the brain, indicating the need for reliable functional measures in MS. We investigated whether altered resting-state oscillatory power could be related to clinical and cognitive dysfunction in MS. MEG recordings were acquired using a 151-channel whole-head MEG system from 21 relapsing remitting MS patients and 17 healthy age-, gender-, and education-matched controls, using an eyes-closed no-task condition. Relative spectral power was estimated for 78 regions of interest, using an atlas-based beamforming approach, for classical frequency bands; delta, theta, alpha1, alpha2, beta and gamma. These cortical power estimates were compared between groups by means of permutation analysis and correlated with clinical disability (Expanded Disability Status Scale: EDSS), cognitive performance and MRI measures of atrophy and lesion load. Patients showed increased power in the alpha1 band and decreased power in the alpha2 band, compared to controls, mainly in occipital, parietal and temporal areas, confirmed by a lower alpha peak-frequency. Increased power in the alpha1 band was associated with worse overall cognition and especially with information processing speed. Our quantitative relative power analysis of MEG recordings showed abnormalities in oscillatory brain dynamics in MS patients in the alpha band. By applying source-space analyses, this study provides a detailed topographical view of abnormal brain activity in MS patients, especially localized to occipital areas. Interestingly, poor cognitive performance was related to high resting-state alpha1 power indicating that changes in oscillatory activity might be of value as an objective measure of disease burden in MS patients.
KW - Atlas
KW - Beamforming
KW - Cognition
KW - Expanded Disability Status Scale
KW - Multiple Sclerosis
KW - Oscillatory activity
KW - Resting-state MEG
UR - http://www.scopus.com/inward/record.url?scp=84879071801&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2013.05.003
DO - 10.1016/j.nicl.2013.05.003
M3 - Article
AN - SCOPUS:84879071801
SN - 2213-1582
VL - 2
SP - 727
EP - 734
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
IS - 1
ER -