Cognitive bias modification training (IVY) countering fatigue in people with breast cancer: A waitlist-control feasibility study

Objectives: The feasibility of a fatigue Cognitive Bias Modification training was evaluated in women on treatment for breast cancer in a multi-center waitlist-control design assessing feasibility criteria, such as recruitment, retention, and completion rates, as well as effects on fatigue bias. Methods: Five hospitals were each asked to recruit 30 patients, who were sequentially divided in active and delayed treatment groups. Fatigue bias and self-reported outcomes (fatigue, vitality, avoidance, and all-or-nothing behavior) were measured in baseline, training, and follow-up phases. Results: Feasibility results were mixed with recruitment and retention not meeting predetermined criteria, but completion and variability were judged positively. Training effects on fatigue bias compared to control were found. Conclusions: This study evaluated a promising novel fatigue intervention. Continuation with an RCT is encouraged with recruitment and retention strategies reconsidered. Trial registry: This study’s protocol (Geerts, et al., 2024) was preregistered at the Open Science Framework on October 31st, 2023.