Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

M. Jurna, M. Windbergs, C.J. Strachan, Liesbeth Hartsuiker, Cornelis Otto, P. Kleinebudde, Jennifer Lynn Herek, Herman L. Offerhaus

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate. This visualization technique can aid future tablet design.
Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalJournal of innovative optical health sciences
Volume2
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • IR-72656
  • METIS-256149

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