Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

M. Jurna; M. Windbergs; C.J. Strachan; Liesbeth Hartsuiker; Cornelis Otto; P. Kleinebudde; Jennifer Lynn Herek; Herman L. Offerhaus

doi:10.1142/S1793545809000322

Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

M. Jurna, M. Windbergs, C.J. Strachan, Liesbeth Hartsuiker, Cornelis Otto, P. Kleinebudde, Jennifer Lynn Herek, Herman L. Offerhaus

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate. This visualization technique can aid future tablet design.

Original language	English
Pages (from-to)	37-43
Number of pages	7
Journal	Journal of innovative optical health sciences
Volume	2
Issue number	1
DOIs	https://doi.org/10.1142/S1793545809000322
Publication status	Published - 2009

Keywords

IR-72656
METIS-256149

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10.1142/S1793545809000322

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title = "Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets",

abstract = "Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate. This visualization technique can aid future tablet design.",

keywords = "IR-72656, METIS-256149",

author = "M. Jurna and M. Windbergs and C.J. Strachan and Liesbeth Hartsuiker and Cornelis Otto and P. Kleinebudde and Herek, {Jennifer Lynn} and Offerhaus, {Herman L.}",

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AU - Jurna, M.

AU - Windbergs, M.

AU - Strachan, C.J.

AU - Hartsuiker, Liesbeth

AU - Otto, Cornelis

AU - Kleinebudde, P.

AU - Herek, Jennifer Lynn

AU - Offerhaus, Herman L.

PY - 2009

Y1 - 2009

N2 - Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate. This visualization technique can aid future tablet design.

AB - Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate. This visualization technique can aid future tablet design.

KW - IR-72656

KW - METIS-256149

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DO - 10.1142/S1793545809000322

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JO - Journal of innovative optical health sciences

JF - Journal of innovative optical health sciences

SN - 1793-5458

IS - 1

ER -

Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

Abstract

Keywords

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