Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation

B. Siebum; Dirk W. Grijpma; Andreas A. Poot; I. Vermes; W. Kruijer; Jan Feijen

doi:10.1016/j.jconrel.2004.09.006

Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation

B. Siebum
, Dirk W. Grijpma
, Andreas A. Poot
, I. Vermes
, W. Kruijer
, Jan Feijen

Research output: Contribution to journal › Meeting Abstract › Other research output

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Abstract

Controlled expansion and differentiation of primitive hematopoietic progenitor cells (HPCs) could allow the transfusion of specific blood cells in large quantities in patients treated with high dose chemo- or radiotherapy. In this study, we introduce the development of a novel, tissue engineering inspired approach to HPC expansion. We present the development of porous crosslinked collagen structures that allow proliferation of HPC-like cells and that can be further modified to create an optimal environment for HPCs to expand and differentiate.

Original language	English
Pages (from-to)	338-340
Journal	Journal of controlled release
Volume	101
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jconrel.2004.09.006
Publication status	Published - 7 Apr 2005
Event	8th European Symposium on Controlled Drug Delivery, ESCDD 2004 - Noordwijk aan Zee, Netherlands Duration: 7 Apr 2004 → 9 Apr 2004 Conference number: 8

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10.1016/j.jconrel.2004.09.006

SiebumFinal published version, 208 KB

Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation
Siebum, B., Grijpma, D. W., Poot, A. A., Vermes, I., Kruijer, W. & Feijen, J., 16 Dec 2003. 1 p.
Research output: Contribution to conference › Poster › Other research output
Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation
Siebum, B., Grijpma, D. W., Poot, A. A., Vermes, I., Kruijer, W. & Feijen, J., 27 Oct 2003, p. 95-97.
Research output: Contribution to conference › Paper

Cite this

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title = "Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation",

abstract = "Controlled expansion and differentiation of primitive hematopoietic progenitor cells (HPCs) could allow the transfusion of specific blood cells in large quantities in patients treated with high dose chemo- or radiotherapy. In this study, we introduce the development of a novel, tissue engineering inspired approach to HPC expansion. We present the development of porous crosslinked collagen structures that allow proliferation of HPC-like cells and that can be further modified to create an optimal environment for HPCs to expand and differentiate.",

author = "B. Siebum and Grijpma, \{Dirk W.\} and Poot, \{Andreas A.\} and I. Vermes and W. Kruijer and Jan Feijen",

year = "2005",

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pages = "338--340",

journal = "Journal of controlled release",

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TY - JOUR

T1 - Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation

AU - Siebum, B.

AU - Grijpma, Dirk W.

AU - Poot, Andreas A.

AU - Vermes, I.

AU - Kruijer, W.

AU - Feijen, Jan

N1 - Conference code: 8

PY - 2005/4/7

Y1 - 2005/4/7

N2 - Controlled expansion and differentiation of primitive hematopoietic progenitor cells (HPCs) could allow the transfusion of specific blood cells in large quantities in patients treated with high dose chemo- or radiotherapy. In this study, we introduce the development of a novel, tissue engineering inspired approach to HPC expansion. We present the development of porous crosslinked collagen structures that allow proliferation of HPC-like cells and that can be further modified to create an optimal environment for HPCs to expand and differentiate.

AB - Controlled expansion and differentiation of primitive hematopoietic progenitor cells (HPCs) could allow the transfusion of specific blood cells in large quantities in patients treated with high dose chemo- or radiotherapy. In this study, we introduce the development of a novel, tissue engineering inspired approach to HPC expansion. We present the development of porous crosslinked collagen structures that allow proliferation of HPC-like cells and that can be further modified to create an optimal environment for HPCs to expand and differentiate.

U2 - 10.1016/j.jconrel.2004.09.006

DO - 10.1016/j.jconrel.2004.09.006

M3 - Meeting Abstract

SN - 0168-3659

VL - 101

SP - 338

EP - 340

JO - Journal of controlled release

JF - Journal of controlled release

IS - 1-3

T2 - 8th European Symposium on Controlled Drug Delivery, ESCDD 2004

Y2 - 7 April 2004 through 9 April 2004

ER -

Collagen scaffolds for hematopoietic progenitor cell expansion and controlled differentiation

Abstract

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