Combination of calix[4]arenes and resorcin[4]arenes for the complexation of steroids

Irene Higler, Peter Timmerman, Willem Verboom, David N. Reinhoudt

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Receptor molecules with large cavities synthesized by the combination of building blocks that already possess a cavity, viz. calix[4]arenes and resorcin[4]arenes, are described. These receptor molecules are synthesized by reaction of one or two upper rim 1,2-difunctionalized calix[4]arene fragments oriented either endo or exo toward a cavitand unit. The endo:exo ratio depends on the substituents at the 3- and 4-positions of the calix[4]arenes. These novel receptor molecules complex steroids with association constants of (0.9−9.5) × 102 M-1 in CDCl3.
Original languageEnglish
Pages (from-to)5920-5931
JournalThe journal of organic chemistry
Issue number17
Publication statusPublished - 1996


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