The procedure for the combinatorial fabrication of new sensing materials for cations and anions based on self-assembled monolayers (SAM) is discussed. A library of different sensitive substrates is generated by sequential deposition of fluorophores and small ligand molecules onto an amino-terminated SAM coated glass. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on individually deposited small molecules. Additionally the sensing system has been miniaturized to the microscale using microcontact printing and integrating the sensory SAMs on the walls of microchannels.
|Title of host publication||Frontiers in Chemical Sensors|
|Subtitle of host publication||novel principles and techniques|
|Editors||Guillermo Orellana, Maria C. Moreno-Bondi|
|Place of Publication||Berlin, Germany|
|Number of pages||20|
|Publication status||Published - 2005|
|Name||Springer series on chemical sensors and biosensors|