Combinatorial method for surface-confined sensor design and fabrication

M.L. Basabe Desmonts, R.S. Zimmerman, David Reinhoudt, Mercedes Crego Calama

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    Abstract

    The procedure for the combinatorial fabrication of new sensing materials for cations and anions based on self-assembled monolayers (SAM) is discussed. A library of different sensitive substrates is generated by sequential deposition of fluorophores and small ligand molecules onto an amino-terminated SAM coated glass. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on individually deposited small molecules. Additionally the sensing system has been miniaturized to the microscale using microcontact printing and integrating the sensory SAMs on the walls of microchannels.
    Original languageEnglish
    Title of host publicationFrontiers in Chemical Sensors
    Subtitle of host publicationnovel principles and techniques
    EditorsGuillermo Orellana, Maria C. Moreno-Bondi
    Place of PublicationBerlin, Germany
    PublisherSpringer
    Pages169-188
    Number of pages20
    ISBN (Print)978-3-540-27756-9
    DOIs
    Publication statusPublished - 2005

    Publication series

    NameSpringer series on chemical sensors and biosensors
    PublisherSpringer-Verlag
    Number3
    Volume3

    Keywords

    • METIS-229073
    • IR-85866

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