Combined optical and acoustical detection of single microbubble dynamics

J. Sijl, Hendrik J. Vos, Timo Rozendal, N. de Jong, Detlef Lohse, Michel Versluis

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.
Original languageUndefined
Pages (from-to)3271-3281
Number of pages11
JournalJournal of the Acoustical Society of America
Volume30
Issue number5
DOIs
Publication statusPublished - 2011

Keywords

  • IR-79055
  • Bubbles
  • drug delivery systems
  • nonlinear acoustics
  • METIS-279952
  • biomedical ultrasonics
  • ultrasonic measurement
  • ultrasonic transducers
  • biomedical materials

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