Combined optical sizing and acoustical characterization of single freely-floating microbubbles

Ying Luan, Guillaume Renaud, Jason L. Raymond, T.J. Segers, Guillaume Pierre Rene Lajoinie, Robert Beurskens, Frits Mastik, Tom J.A. Kokhuis, Antonius F.W. van der Steen, Michel Versluis, N. de Jong

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Abstract

In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a streamline within the confocal region of three ultrasound transducers and a high-resolution microscope objective. Bright-field images of microbubbles passing through the confocal region were captured using a high-speed camera synchronized to the acoustical data acquisition to assess the microbubble response to a 1-MHz ultrasound burst. Nonlinear bubble vibrations were identified at a driving pressure as low as 50 kPa. The results demonstrate good agreement with numerical simulations based on the shell-buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)]. The system demonstrates the potential for a high-throughput in vitro characterization of individual microbubbles.
Original languageEnglish
Pages (from-to)234104-
Number of pages6
JournalApplied physics letters
Volume109
Issue number23
DOIs
Publication statusPublished - 2016

Keywords

  • IR-103911
  • METIS-320746

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