Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Chetan A. Patil; Nienke Bosschaart; Matthew D. Keller; Ton van Leeuwen; Anita Mahadevan-Jansen

doi:10.1364/OL.33.001135

Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Chetan A. Patil, Nienke Bosschaart, Matthew D. Keller, Ton van Leeuwen, Anita Mahadevan-Jansen

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Abstract

coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.

Original language	English
Pages (from-to)	1135-1137
Number of pages	3
Journal	Optics letters
Volume	33
Issue number	10
DOIs	https://doi.org/10.1364/OL.33.001135
Publication status	Published - 2008

Keywords

IR-71716
METIS-252429

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10.1364/OL.33.001135

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title = "Combined Raman spectroscopy and optical coherence tomography device for tissue characterization",

abstract = "coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.",

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AU - Patil, Chetan A.

AU - Bosschaart, Nienke

AU - Keller, Matthew D.

AU - van Leeuwen, Ton

AU - Mahadevan-Jansen, Anita

PY - 2008

Y1 - 2008

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AB - coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.

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KW - METIS-252429

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DO - 10.1364/OL.33.001135

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VL - 33

SP - 1135

EP - 1137

JO - Optics letters

JF - Optics letters

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Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Abstract

Keywords

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