Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Chetan A. Patil, Nienke Bosschaart, Matthew D. Keller, Ton van Leeuwen, Anita Mahadevan-Jansen

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Abstract

coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.
Original languageEnglish
Pages (from-to)1135-1137
Number of pages3
JournalOptics letters
Volume33
Issue number10
DOIs
Publication statusPublished - 2008

Keywords

  • IR-71716
  • METIS-252429

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