Combining Psychophysical and EEG Biomarkers for Improved Observation of Altered Nociceptive Processing in Failed Back Surgery Syndrome

Boudewijn van den Berg, Tom Berfelo, Elisa M.H. Verhoeven, Imre P. Krabbenbos, Jan R. Buitenweg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
62 Downloads (Pure)

Abstract

Diagnosis and stratification of chronic pain patients is difficult due to a lack of sensitive biomarkers for altered nociceptive and pain processing. Recent developments enabled to preferentially stimulate epidermal nerve fibers and simultaneously quantify the psychophysical detection probability and neurophysiological EEG responses. In this work, we study whether using one or a combination of both outcome measures could aid in the observation of altered nociceptive processing in chronic pain. A set of features was extracted from data from a total of 66 measurements on 16 failed back surgery syndrome patients and 17 healthy controls. We assessed how well each feature discriminates both groups. Subsequently, we used a random forest classifier to study whether psychophysical features, EEG features or a combination can improve the classification accuracy. It was found that a classification accuracy of 0.77 can be achieved with psychophysical features, while a classification accuracy of 0.65 was achieved using only EEG features.Clinical Relevance-This study shows which combined features of nociceptive detection behavior and evoked EEG responses are most sensitive and specific to altered nociception in failed back surgery syndrome.

Original languageEnglish
Title of host publication2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages174-177
Number of pages4
ISBN (Electronic)978-1-7281-1179-7, 978-1-7281-1178-0 (USB)
ISBN (Print)978-1-7281-1180-3
DOIs
Publication statusPublished - 9 Dec 2021
Event43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2021: Changing Global Health Care in the Twenty-First Century - Virtual
Duration: 1 Nov 20215 Nov 2021
Conference number: 43

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Volume 2021
ISSN (Print)2375-7477
ISSN (Electronic)2694-0604

Conference

Conference43rd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Abbreviated titleEMBC
Period1/11/215/11/21

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