Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex

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Abstract

Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.
Original languageUndefined
Pages (from-to)471-478
Number of pages8
JournalJournal of clinical neurophysiology
Volume27
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • METIS-272549
  • IR-75067
  • Bifurcation analysis
  • Modeling
  • Delay differential equation
  • Neocortex
  • Epilepsy
  • Oscillation
  • EWI-18857
  • MSC-34K18
  • MSC-34K60

Cite this

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title = "Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex",
abstract = "Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.",
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author = "S. Visser and Meijer, {Hil Ga{\'e}tan Ellart} and Lee, {Hyong C.} and {van Drongelen}, Wim and {van Putten}, {Michel Johannes Antonius Maria} and {van Gils}, {Stephanus A.}",
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volume = "27",
pages = "471--478",
journal = "Journal of clinical neurophysiology",
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Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex. / Visser, S.; Meijer, Hil Gaétan Ellart; Lee, Hyong C.; van Drongelen, Wim; van Putten, Michel Johannes Antonius Maria; van Gils, Stephanus A.

In: Journal of clinical neurophysiology, Vol. 27, No. 6, 12.2010, p. 471-478.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex

AU - Visser, S.

AU - Meijer, Hil Gaétan Ellart

AU - Lee, Hyong C.

AU - van Drongelen, Wim

AU - van Putten, Michel Johannes Antonius Maria

AU - van Gils, Stephanus A.

PY - 2010/12

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AB - Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.

KW - METIS-272549

KW - IR-75067

KW - Bifurcation analysis

KW - Modeling

KW - Delay differential equation

KW - Neocortex

KW - Epilepsy

KW - Oscillation

KW - EWI-18857

KW - MSC-34K18

KW - MSC-34K60

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DO - 10.1097/WNP.0b013e3181fe0735

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JO - Journal of clinical neurophysiology

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