Objective. To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose. Methods. In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation. Results. Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes. Conclusion. An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis.
Popma, J. W., Snel, F. W., Haagsma, C. J., Brummelhuis-Visser, P., Oldenhof, H. G. J., van der Palen, J. A. M., & van de Laar, M. A. F. J. (2015). Comparison of 2 dosages of intraarticular triamcinolone for the treatment of knee arthritis: results of a 12-week randomized controlled clinical trial. Journal of rheumatology, 42(10), 1865-1868. https://doi.org/10.3899/jrheum.141630