TY - JOUR
T1 - Comparison of a Free-Breathing CT and an Expiratory Breath-Hold CT with Regard to Spatial Alignment of Amplitude-Based Respiratory-Gated PET and CT Images
AU - van der Vos, Charlotte S.
AU - Grootjans, Willem
AU - Meeuwis, Antoi P.W.
AU - Slump, Cornelis H.
AU - Oyen, Wim J.G.
AU - de Geus-Oei, Lioe-Fee
AU - Visser, Eric P.
PY - 2014
Y1 - 2014
N2 - Respiratory motion during PET has a significant effect on the quantification of radiotracer uptake in PET images. Even when respiratory motion is considered using PET gating techniques, inaccuracies in standardized uptake values can be caused by inappropriate attenuation correction due to a spatial mismatch between PET and CT. In this study, the effect of breath-hold CT imaging on the spatial match between CT and amplitude-based respiratory-gated PET images is investigated. Methods: Whole-body 18F-FDG PET/CT imaging was performed in 52 patients with 125 lung lesions. 18F-FDG PET was performed using optimized, amplitude-based respiratory gating. For CT, 36 patients were randomly assigned to the free-breathing (FB) group and 16 to the rest-expiratory breath-hold (BH) group. Spatial mismatch between the PET and CT images was quantified by measuring the distance between the centroids of PET and CT lesions and calculating the Jaccard similarity coefficient (JSC). Results: In the upper lobes, the average distance between the centroids of the PET and CT lesions was 4.7 ± 3.1 and 6.0 ± 3.0 mm for the FB and BH groups, respectively (P = 0.11). For the middle and lower lobes, the distances were 5.8 ± 4.3 and 5.1 ± 2.9 mm (P = 0.70), respectively, and for the central region 4.8 ± 4.6 and 5.6 ± 2.0 mm (P = 0.24), respectively. The JSC for the upper lobes was 0.28 ± 0.17 and 0.28 ± 0.19, for the FB and the BH group, respectively (P = 0.83). For the middle and lower lobes, the JSC was 0.22 ± 0.16 and 0.28 ± 0.18 (P = 0.20), respectively, and for the central region 0.39 ± 0.17 and 0.13 ± 0.04 (P = 0.04), respectively. Conclusion: Providing breathing instructions to the patients during the CT acquisition did not improve the spatial alignment between the respiratory-gated PET images and the CT images. The difficulty experienced in using this clinical protocol, such as patient compliance and operator dependence, emphasizes the need for other strategies
AB - Respiratory motion during PET has a significant effect on the quantification of radiotracer uptake in PET images. Even when respiratory motion is considered using PET gating techniques, inaccuracies in standardized uptake values can be caused by inappropriate attenuation correction due to a spatial mismatch between PET and CT. In this study, the effect of breath-hold CT imaging on the spatial match between CT and amplitude-based respiratory-gated PET images is investigated. Methods: Whole-body 18F-FDG PET/CT imaging was performed in 52 patients with 125 lung lesions. 18F-FDG PET was performed using optimized, amplitude-based respiratory gating. For CT, 36 patients were randomly assigned to the free-breathing (FB) group and 16 to the rest-expiratory breath-hold (BH) group. Spatial mismatch between the PET and CT images was quantified by measuring the distance between the centroids of PET and CT lesions and calculating the Jaccard similarity coefficient (JSC). Results: In the upper lobes, the average distance between the centroids of the PET and CT lesions was 4.7 ± 3.1 and 6.0 ± 3.0 mm for the FB and BH groups, respectively (P = 0.11). For the middle and lower lobes, the distances were 5.8 ± 4.3 and 5.1 ± 2.9 mm (P = 0.70), respectively, and for the central region 4.8 ± 4.6 and 5.6 ± 2.0 mm (P = 0.24), respectively. The JSC for the upper lobes was 0.28 ± 0.17 and 0.28 ± 0.19, for the FB and the BH group, respectively (P = 0.83). For the middle and lower lobes, the JSC was 0.22 ± 0.16 and 0.28 ± 0.18 (P = 0.20), respectively, and for the central region 0.39 ± 0.17 and 0.13 ± 0.04 (P = 0.04), respectively. Conclusion: Providing breathing instructions to the patients during the CT acquisition did not improve the spatial alignment between the respiratory-gated PET images and the CT images. The difficulty experienced in using this clinical protocol, such as patient compliance and operator dependence, emphasizes the need for other strategies
KW - 2023 OA procedure
U2 - 10.2967/jnmt.114.145748
DO - 10.2967/jnmt.114.145748
M3 - Article
SN - 0161-5505
VL - 42
SP - 269
EP - 273
JO - The Journal of nuclear medicine
JF - The Journal of nuclear medicine
IS - 4
ER -