Comparison of dynamic susceptibility contrast-MRI perfusion quantification methods in the presence of delay and dispersion

Bianca Maan, Rita Lopes Simoes, Frederick J.A Meijer, W. Klaas Jan Renema, Cornelis H. Slump

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

    Abstract

    The perfusion of the brain is essential to maintain brain function. Stroke is an example of a decrease in blood flow and reduced perfusion. During ischemic stroke the blood flow to tissue is hampered due to a clot inside a vessel. To investigate the recovery of stroke patients, follow up studies are necessary. MRI is the preferred imaging modality for follow up because of the absence of radiation dose concerns, contrary to CT. Dynamic Susceptibility Contrast (DSC) MRI is an imaging technique used for measuring perfusion of the brain, however, is not standard applied in the clinical routine due to lack of immediate patient benefit. Several post processing algorithms are described in the literature to obtain cerebral blood flow (CBF). The quantification of CBF relies on the deconvolution of a tracer concentration-time curve in an arterial and a tissue voxel. There are several methods to obtain this deconvolution based on singular-value decomposition (SVD). This contribution describes a comparison between the different approaches as currently there is no best practice for (all) clinical relevant situations. We investigate the influence of tracer delay, dispersion and recirculation on the performance of the methods. In the presence of negative delays, the truncated SVD approach overestimates the CBF. Block-circulant and reformulated SVD are delay-independent. Due to its delay dependent behavior, the truncated SVD approach performs worse in the presence of dispersion as well. However all SVD approaches are dependent on the amount of dispersion. Moreover, we observe that the optimal truncation parameter varies when recirculation is added to noisy data, suggesting that, in practice, these methods are not immune to tracer recirculation. Finally, applying the methods to clinical data resulted in a large variability of the CBF estimates. Block-circulant SVD will work in all situations and is the method with the highest potential.
    Original languageUndefined
    Title of host publicationMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
    EditorsJohn B. Weaver, Robert C. Molthen
    PublisherSPIE
    Pages79652C
    Number of pages13
    ISBN (Print)978-0-81948-507-6
    DOIs
    Publication statusPublished - 15 Mar 2011
    EventSPIE Medical Imaging 2011 - Lake Buena Vista, United States
    Duration: 12 Feb 201117 Feb 2011

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume7965

    Conference

    ConferenceSPIE Medical Imaging 2011
    CountryUnited States
    CityLake Buena Vista
    Period12/02/1117/02/11

    Keywords

    • METIS-277723
    • IR-77721
    • Deconvolution
    • block-circulant SVD
    • Perfusion
    • EWI-20346
    • Dynamic susceptibility contrast
    • Singular value decomposition
    • reformulated SVD
    • recirculation
    • Stroke

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