Comparison of scanning beam and whole field laser Doppler perfusion imaging

Wiendelt Steenbergen, Erwin Hondebrink, Matthijs Draijer, Ton van Leeuwen

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Currently, laser perfusion imaging (LDPI) is undergoing a technology shift from scanning beam perfusion imagers to whole field systems. The latter can be subdivided in laser Doppler methods systems based on high speed CMOS cameras, and laser speckle contrast analysis (LASCA) technologies using slow imaging arrays, mostly CCD-based. In scanning beam systems, a collimated laser beam scans the tissue with diffusely back reflected light being captured with a single detector. In whole field systems a large tissue area is illuminated, and the reflected light is imaged onto an array and captured at once. Unlike scanning beam systems, both whole field methods enable perfusion imaging at video rate. In this study we experimentally compare the scanning beam LDPI principle with whole field LDPI, using Intralipid phantoms. For the tissue phantoms, the Monte Carlo simulation technique will be used as a reference. From measurements on Intralipid phantoms compared to Monte Carlo, we conclude that in whole field LDPI the flux image, representing the first order moment of the power spectrum of photocurrent fluctuations is much closer related to real perfusion than for scanning beam systems. This difference can be explained in terms of the different behaviour of dynamic speckle patterns generated in both methods, in response to varying tissue optical properties
Original languageEnglish
Title of host publicationDynamics and Fluctuations in Biomedical Photonics VII
EditorsValery V. Tuchin, Donald D. Duncan, Kirill V. Larin
PublisherSPIE - The International Society for Optical Engineering
Pages75630H
ISBN (Print)9780819479594
DOIs
Publication statusPublished - 2010

Publication series

NameProceedings of SPIE
PublisherSPIE--The International Society for Optical Engineering
Volume7563
ISSN (Print)0277-786X

Keywords

  • IR-77700

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  • Cite this

    Steenbergen, W., Hondebrink, E., Draijer, M., & van Leeuwen, T. (2010). Comparison of scanning beam and whole field laser Doppler perfusion imaging. In V. V. Tuchin, D. D. Duncan, & K. V. Larin (Eds.), Dynamics and Fluctuations in Biomedical Photonics VII (pp. 75630H). (Proceedings of SPIE; Vol. 7563). SPIE - The International Society for Optical Engineering. https://doi.org/10.1117/12.841793