Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles

Q. Hu, Cristianne J. Rijcken, Ruchi Bansal, Wim E. Hennink, Gerrit Storm, Jai Prakash

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Treatment with chemotherapy such as docetaxel (DTX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to CCL-PMs via a hydrolysable ester bond. The covalent conjugation allowed for sustained release of DTX under physiological conditions in vitro. In vivo, DTX-CCL-PMs demonstrated superior therapeutic efficacy in mice bearing MDA-MB-231 tumour xenografts as compared to the marketed formulation of DTX (Taxotere®). Strikingly, a single intravenous injection of DTX-CCL-PMs enabled complete regression of both small (∼150 mm3) and established (∼550 mm3) tumours, leading to 100% survival of the animals. These remarkable antitumour effects of DTX-CCL-PMs are attributed to its enhanced tumour accumulation and anti-stromal activity. Furthermore, DTX-CCL-PMs exhibited superior tolerability in healthy rats as compared to Taxotere. These preclinical data strongly support clinical translation of this novel nanomedicinal product for the treatment of cancer
Original languageUndefined
Pages (from-to)370-378
JournalBiomaterials
Volume53
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-310435
  • IR-95812

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