Complex Tissue and Disease Modeling using hiPSCs

Robert Passier, Valeria V. Orlova, Christine Mummery

Research output: Contribution to journalReview articleAcademicpeer-review

56 Citations (Scopus)
27 Downloads (Pure)

Abstract

Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses will only be evident if all cellular and extracellular components of a tissue are present and functionally mature. To derive optimal benefit from such models, complex multicellular structures with vascular components that mimic tissue niches will thus likely be necessary. Here we consider emerging research creating human tissue mimics and provide some recommendations for moving the field forward.

Original languageEnglish
Pages (from-to)309-321
Number of pages13
JournalCell stem cell
Volume18
Issue number3
DOIs
Publication statusPublished - 3 Mar 2016

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Pluripotent Stem Cells
Preclinical Drug Evaluations
Genetic Models
Blood Vessels
Phenotype
Research
Pharmaceutical Preparations

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Passier, Robert ; Orlova, Valeria V. ; Mummery, Christine. / Complex Tissue and Disease Modeling using hiPSCs. In: Cell stem cell. 2016 ; Vol. 18, No. 3. pp. 309-321.
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Complex Tissue and Disease Modeling using hiPSCs. / Passier, Robert; Orlova, Valeria V.; Mummery, Christine.

In: Cell stem cell, Vol. 18, No. 3, 03.03.2016, p. 309-321.

Research output: Contribution to journalReview articleAcademicpeer-review

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