Complexation and (templated) synthesis of rhenium complexes with cyclodextrins and cyclodextrin dimers in water

K.J.C. Bommel, M.R. de Jong, Gerald A. Metselaar, Willem Verboom, Jurriaan Huskens, A.J.R.L. Hulst, Huub Kooijman, Anthony L. Spek, David Reinhoudt

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Abstract

Several small, lipophilic rhenium complexes form inclusion complexes with native -cyclodextrin (-CD) and -CD dimers. Association constants larger than 109 M-1 were obtained using dimers. The use of -CD also enabled the synthesis of these rhenium complexes in water, in excellent yields, through complexation of the otherwise insoluble corresponding ligands. The influence of the reaction time and temperature on the configuration of the reaction products has been investigated in depth for one of these complexes. Using a -CD dimer, it proved possible to specifically template the formation of one configuration. The strength of the complexes of the rhenium complexes in cyclodextrin dimers may allow radiolabeling of biomolecules.
Original languageUndefined
Pages (from-to)3603-3615
JournalChemistry: a European journal
Volume7
Issue number16
DOIs
Publication statusPublished - 2001

Keywords

  • templated synthesis
  • Supramolecular Chemistry
  • Rhenium
  • radiopharmaceuticals
  • IR-36747
  • METIS-202967
  • Cyclodextrins

Cite this

Bommel, K.J.C. ; de Jong, M.R. ; Metselaar, Gerald A. ; Verboom, Willem ; Huskens, Jurriaan ; Hulst, A.J.R.L. ; Kooijman, Huub ; Spek, Anthony L. ; Reinhoudt, David. / Complexation and (templated) synthesis of rhenium complexes with cyclodextrins and cyclodextrin dimers in water. In: Chemistry: a European journal. 2001 ; Vol. 7, No. 16. pp. 3603-3615.
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abstract = "Several small, lipophilic rhenium complexes form inclusion complexes with native -cyclodextrin (-CD) and -CD dimers. Association constants larger than 109 M-1 were obtained using dimers. The use of -CD also enabled the synthesis of these rhenium complexes in water, in excellent yields, through complexation of the otherwise insoluble corresponding ligands. The influence of the reaction time and temperature on the configuration of the reaction products has been investigated in depth for one of these complexes. Using a -CD dimer, it proved possible to specifically template the formation of one configuration. The strength of the complexes of the rhenium complexes in cyclodextrin dimers may allow radiolabeling of biomolecules.",
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journal = "Chemistry: a European journal",
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Complexation and (templated) synthesis of rhenium complexes with cyclodextrins and cyclodextrin dimers in water. / Bommel, K.J.C.; de Jong, M.R.; Metselaar, Gerald A.; Verboom, Willem; Huskens, Jurriaan; Hulst, A.J.R.L.; Kooijman, Huub; Spek, Anthony L.; Reinhoudt, David.

In: Chemistry: a European journal, Vol. 7, No. 16, 2001, p. 3603-3615.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Complexation and (templated) synthesis of rhenium complexes with cyclodextrins and cyclodextrin dimers in water

AU - Bommel, K.J.C.

AU - de Jong, M.R.

AU - Metselaar, Gerald A.

AU - Verboom, Willem

AU - Huskens, Jurriaan

AU - Hulst, A.J.R.L.

AU - Kooijman, Huub

AU - Spek, Anthony L.

AU - Reinhoudt, David

N1 - 654

PY - 2001

Y1 - 2001

N2 - Several small, lipophilic rhenium complexes form inclusion complexes with native -cyclodextrin (-CD) and -CD dimers. Association constants larger than 109 M-1 were obtained using dimers. The use of -CD also enabled the synthesis of these rhenium complexes in water, in excellent yields, through complexation of the otherwise insoluble corresponding ligands. The influence of the reaction time and temperature on the configuration of the reaction products has been investigated in depth for one of these complexes. Using a -CD dimer, it proved possible to specifically template the formation of one configuration. The strength of the complexes of the rhenium complexes in cyclodextrin dimers may allow radiolabeling of biomolecules.

AB - Several small, lipophilic rhenium complexes form inclusion complexes with native -cyclodextrin (-CD) and -CD dimers. Association constants larger than 109 M-1 were obtained using dimers. The use of -CD also enabled the synthesis of these rhenium complexes in water, in excellent yields, through complexation of the otherwise insoluble corresponding ligands. The influence of the reaction time and temperature on the configuration of the reaction products has been investigated in depth for one of these complexes. Using a -CD dimer, it proved possible to specifically template the formation of one configuration. The strength of the complexes of the rhenium complexes in cyclodextrin dimers may allow radiolabeling of biomolecules.

KW - templated synthesis

KW - Supramolecular Chemistry

KW - Rhenium

KW - radiopharmaceuticals

KW - IR-36747

KW - METIS-202967

KW - Cyclodextrins

U2 - 10.1002/1521-3765(20010817)7:16<3603::AID-CHEM3603>3.0.CO;2-E

DO - 10.1002/1521-3765(20010817)7:16<3603::AID-CHEM3603>3.0.CO;2-E

M3 - Article

VL - 7

SP - 3603

EP - 3615

JO - Chemistry: a European journal

JF - Chemistry: a European journal

SN - 0947-6539

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ER -