Complexation of neutral molecules by synthetic hosts

David Reinhoudt; F.C.J.M. van Veggel

doi:10.1351/pac199365050965

Complexation of neutral molecules by synthetic hosts

David Reinhoudt, F.C.J.M. van Veggel

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Abstract

The interactions of neutral polar molecules with synthetic (macrocyclic) hosts are described. Extraction, NMR spectroscopy, polarography, and membrane transport studies have been carried out in order to understand these interactions. A step-wise process is described in which ultimately a general approach for a rational design of hosts is obtained. This approach has finally led to the first transfer of urea across a membrane by a neutral host (carrier) in which binding sites are placed in such a way that all possible interactions with urea are indeed used.

Original language	Undefined
Pages (from-to)	965-969
Journal	Pure and applied chemistry
Volume	65
Issue number	65
DOIs	https://doi.org/10.1351/pac199365050965
Publication status	Published - 1993

Keywords

METIS-106584
IR-12280

Access to Document

10.1351/pac199365050965

K12280__

Cite this

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abstract = "The interactions of neutral polar molecules with synthetic (macrocyclic) hosts are described. Extraction, NMR spectroscopy, polarography, and membrane transport studies have been carried out in order to understand these interactions. A step-wise process is described in which ultimately a general approach for a rational design of hosts is obtained. This approach has finally led to the first transfer of urea across a membrane by a neutral host (carrier) in which binding sites are placed in such a way that all possible interactions with urea are indeed used.",

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author = "David Reinhoudt and {van Veggel}, F.C.J.M.",

note = "12th IUPAC Conference on Chemical Thermodynamics, Snowbird, Utah, USA, 16–21 August 1992 ",

year = "1993",

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AU - van Veggel, F.C.J.M.

N1 - 12th IUPAC Conference on Chemical Thermodynamics, Snowbird, Utah, USA, 16–21 August 1992

PY - 1993

Y1 - 1993

N2 - The interactions of neutral polar molecules with synthetic (macrocyclic) hosts are described. Extraction, NMR spectroscopy, polarography, and membrane transport studies have been carried out in order to understand these interactions. A step-wise process is described in which ultimately a general approach for a rational design of hosts is obtained. This approach has finally led to the first transfer of urea across a membrane by a neutral host (carrier) in which binding sites are placed in such a way that all possible interactions with urea are indeed used.

AB - The interactions of neutral polar molecules with synthetic (macrocyclic) hosts are described. Extraction, NMR spectroscopy, polarography, and membrane transport studies have been carried out in order to understand these interactions. A step-wise process is described in which ultimately a general approach for a rational design of hosts is obtained. This approach has finally led to the first transfer of urea across a membrane by a neutral host (carrier) in which binding sites are placed in such a way that all possible interactions with urea are indeed used.

KW - METIS-106584

KW - IR-12280

U2 - 10.1351/pac199365050965

DO - 10.1351/pac199365050965

M3 - Article

SN - 0033-4545

VL - 65

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JO - Pure and applied chemistry

JF - Pure and applied chemistry

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