Complexation of neutral molecules by synthetic hosts

David Reinhoudt, F.C.J.M. van Veggel

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    The interactions of neutral polar molecules with synthetic (macrocyclic) hosts are described. Extraction, NMR spectroscopy, polarography, and membrane transport studies have been carried out in order to understand these interactions. A step-wise process is described in which ultimately a general approach for a rational design of hosts is obtained. This approach has finally led to the first transfer of urea across a membrane by a neutral host (carrier) in which binding sites are placed in such a way that all possible interactions with urea are indeed used.
    Original languageUndefined
    Pages (from-to)965-969
    JournalPure and applied chemistry
    Issue number65
    Publication statusPublished - 1993


    • METIS-106584
    • IR-12280

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