Composite biomaterials with chemical bonding between hydroxyapatite filler particles and PEG/PBT copolymer matrix

Qing Liu, Joost R. de Wijn, Clemens A. van Blitterswijk

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113 Citations (Scopus)


In an effort to make composites from hydroxyapatite and a PEG/PBT copolymer (PolyactiveTM 70/30), chemical linkages were introduced between the filler particles and polymer matrix using hexamethylene diisocyanate as a coupling agent. Infrared spectra (IR) and thermal gravimetric analysis (TGA) confirmed the presence of PolyactiveTM 70/30 on the surface of HA filler particles. The amount of chemically bound polymer was 4.7 wt.%, as determined by TGA. The mechanical properties of the composites, that is, tensile strength and Young's modulus, were improved significantly by the introduction of a chemical linkage between the filler particles and polymer matrix compared to control composites. This method provides an effective way to introduce chemical linkage between HA filler particles and a polymer matrix. By optimizing the grafting process, a further improvement of the mechanical properties in the composites can be expected.
Original languageEnglish
Pages (from-to)490-497
JournalJournal of biomedical materials research
Issue number3
Publication statusPublished - 1998


  • Composites
  • Coupling agent
  • PolyactiveTM
  • Hydroxyapatite
  • Surface grafting
  • Diisocyanate
  • Interface
  • Mechanical properties

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