"Compression-only" behavior: A second-order nonlinear response of ultrasound contrast agent microbubbles

J. Sijl, M.L.J. Overvelde, B. Dollet, V. Garbin, Valeria Garbin, N. de Jong, Detlef Lohse, Michel Versluis

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Oscillating phospholipid-coated ultrasound contrast agent microbubbles display a so-called “compression-only” behavior, where it is observed that the bubbles compress efficiently while their expansion is suppressed. Here, a theoretical understanding of the source of this nonlinear behavior is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)]. It is shown that the radial dynamics of the bubble can be considered as a superposition of a linear response at the fundamental driving frequency and a second-order nonlinear low-frequency response that describes the negative offset of the mean bubble radius. The analytical solution deduced from the weakly nonlinear analysis shows that the compression-only behavior results from a rapid change of the shell elasticity with bubble radius. In addition, the radial dynamics of single phospholipid-coated microbubbles was recorded as a function of both the amplitude and the frequency of the driving pressure pulse. The comparison between the experimental data and the theory shows that the magnitude of compression-only behavior is mainly determined by the initial phospholipids concentration on the bubble surface, which slightly varies from bubble to bubble
Original languageUndefined
Pages (from-to)1729-1739
Number of pages11
JournalJournal of the Acoustical Society of America
Volume129
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • nonlinear acoustics
  • biomedical ultrasonics
  • Bubbles
  • METIS-274909
  • ultrasonic imaging
  • IR-79074

Cite this

Sijl, J. ; Overvelde, M.L.J. ; Dollet, B. ; Garbin, V. ; Garbin, Valeria ; de Jong, N. ; Lohse, Detlef ; Versluis, Michel. / "Compression-only" behavior: A second-order nonlinear response of ultrasound contrast agent microbubbles. In: Journal of the Acoustical Society of America. 2011 ; Vol. 129, No. 4. pp. 1729-1739.
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abstract = "Oscillating phospholipid-coated ultrasound contrast agent microbubbles display a so-called “compression-only” behavior, where it is observed that the bubbles compress efficiently while their expansion is suppressed. Here, a theoretical understanding of the source of this nonlinear behavior is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)]. It is shown that the radial dynamics of the bubble can be considered as a superposition of a linear response at the fundamental driving frequency and a second-order nonlinear low-frequency response that describes the negative offset of the mean bubble radius. The analytical solution deduced from the weakly nonlinear analysis shows that the compression-only behavior results from a rapid change of the shell elasticity with bubble radius. In addition, the radial dynamics of single phospholipid-coated microbubbles was recorded as a function of both the amplitude and the frequency of the driving pressure pulse. The comparison between the experimental data and the theory shows that the magnitude of compression-only behavior is mainly determined by the initial phospholipids concentration on the bubble surface, which slightly varies from bubble to bubble",
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"Compression-only" behavior: A second-order nonlinear response of ultrasound contrast agent microbubbles. / Sijl, J.; Overvelde, M.L.J.; Dollet, B.; Garbin, V.; Garbin, Valeria; de Jong, N.; Lohse, Detlef; Versluis, Michel.

In: Journal of the Acoustical Society of America, Vol. 129, No. 4, 2011, p. 1729-1739.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Sijl, J.

AU - Overvelde, M.L.J.

AU - Dollet, B.

AU - Garbin, V.

AU - Garbin, Valeria

AU - de Jong, N.

AU - Lohse, Detlef

AU - Versluis, Michel

PY - 2011

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N2 - Oscillating phospholipid-coated ultrasound contrast agent microbubbles display a so-called “compression-only” behavior, where it is observed that the bubbles compress efficiently while their expansion is suppressed. Here, a theoretical understanding of the source of this nonlinear behavior is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)]. It is shown that the radial dynamics of the bubble can be considered as a superposition of a linear response at the fundamental driving frequency and a second-order nonlinear low-frequency response that describes the negative offset of the mean bubble radius. The analytical solution deduced from the weakly nonlinear analysis shows that the compression-only behavior results from a rapid change of the shell elasticity with bubble radius. In addition, the radial dynamics of single phospholipid-coated microbubbles was recorded as a function of both the amplitude and the frequency of the driving pressure pulse. The comparison between the experimental data and the theory shows that the magnitude of compression-only behavior is mainly determined by the initial phospholipids concentration on the bubble surface, which slightly varies from bubble to bubble

AB - Oscillating phospholipid-coated ultrasound contrast agent microbubbles display a so-called “compression-only” behavior, where it is observed that the bubbles compress efficiently while their expansion is suppressed. Here, a theoretical understanding of the source of this nonlinear behavior is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)]. It is shown that the radial dynamics of the bubble can be considered as a superposition of a linear response at the fundamental driving frequency and a second-order nonlinear low-frequency response that describes the negative offset of the mean bubble radius. The analytical solution deduced from the weakly nonlinear analysis shows that the compression-only behavior results from a rapid change of the shell elasticity with bubble radius. In addition, the radial dynamics of single phospholipid-coated microbubbles was recorded as a function of both the amplitude and the frequency of the driving pressure pulse. The comparison between the experimental data and the theory shows that the magnitude of compression-only behavior is mainly determined by the initial phospholipids concentration on the bubble surface, which slightly varies from bubble to bubble

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KW - ultrasonic imaging

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