Computational prediction of mechanical hemolysis in aortic valved protheses

M.D. De Tullio, J. Nam, G. Pascazio, E. Balaras, Roberto Verzicco

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

The paper reports the prediction of mechanical hemolysis by three different models for the case of blood flow through aortic valved prostheses. Two of the adopted models are based on the action of instantaneous shear stress on the blood cells (stress-based), while the third accounts for the finite response time of cell deformation and relaxation (strain-based). Two aortic Dacron grafts commonly adopted in clinical practice are considered, and both are equipped with a bileaflet mechanical valve. One of the grafts reproduces the three sinuses of Valsalva, while the other is a straight tube. A direct numerical simulation approach is utilized to solve the complex fluid-structure-interaction problem and obtain detailed information of the flow patterns. To evaluate hemolysis, a large number of Lagrangian tracer particles were released at the inlet of the computational domain (upstream of the valve), and blood damage was evaluated along each trajectory for each model. We found that stress-based models predict higher levels of blood damage than the strain-based one. The same level of blood damage is observed in the two geometric configurations we considered, indicating that the adopted mechanical valve is primary risk factor for hemolysis.
Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalEuropean journal of mechanics. B, Fluids
Volume35
DOIs
Publication statusPublished - 2012

Fingerprint

hemolysis
Blood
blood
Damage
Prediction
predictions
damage
Dacron (trademark)
sinuses
Complex Fluids
blood cells
Cell
Flow Pattern
Risk Factors
blood flow
Blood Flow
direct numerical simulation
Shear Stress
Model
Straight

Keywords

  • METIS-295669
  • IR-89911

Cite this

De Tullio, M.D. ; Nam, J. ; Pascazio, G. ; Balaras, E. ; Verzicco, Roberto. / Computational prediction of mechanical hemolysis in aortic valved protheses. In: European journal of mechanics. B, Fluids. 2012 ; Vol. 35. pp. 47-53.
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title = "Computational prediction of mechanical hemolysis in aortic valved protheses",
abstract = "The paper reports the prediction of mechanical hemolysis by three different models for the case of blood flow through aortic valved prostheses. Two of the adopted models are based on the action of instantaneous shear stress on the blood cells (stress-based), while the third accounts for the finite response time of cell deformation and relaxation (strain-based). Two aortic Dacron grafts commonly adopted in clinical practice are considered, and both are equipped with a bileaflet mechanical valve. One of the grafts reproduces the three sinuses of Valsalva, while the other is a straight tube. A direct numerical simulation approach is utilized to solve the complex fluid-structure-interaction problem and obtain detailed information of the flow patterns. To evaluate hemolysis, a large number of Lagrangian tracer particles were released at the inlet of the computational domain (upstream of the valve), and blood damage was evaluated along each trajectory for each model. We found that stress-based models predict higher levels of blood damage than the strain-based one. The same level of blood damage is observed in the two geometric configurations we considered, indicating that the adopted mechanical valve is primary risk factor for hemolysis.",
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Computational prediction of mechanical hemolysis in aortic valved protheses. / De Tullio, M.D.; Nam, J.; Pascazio, G.; Balaras, E.; Verzicco, Roberto.

In: European journal of mechanics. B, Fluids, Vol. 35, 2012, p. 47-53.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Computational prediction of mechanical hemolysis in aortic valved protheses

AU - De Tullio, M.D.

AU - Nam, J.

AU - Pascazio, G.

AU - Balaras, E.

AU - Verzicco, Roberto

PY - 2012

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N2 - The paper reports the prediction of mechanical hemolysis by three different models for the case of blood flow through aortic valved prostheses. Two of the adopted models are based on the action of instantaneous shear stress on the blood cells (stress-based), while the third accounts for the finite response time of cell deformation and relaxation (strain-based). Two aortic Dacron grafts commonly adopted in clinical practice are considered, and both are equipped with a bileaflet mechanical valve. One of the grafts reproduces the three sinuses of Valsalva, while the other is a straight tube. A direct numerical simulation approach is utilized to solve the complex fluid-structure-interaction problem and obtain detailed information of the flow patterns. To evaluate hemolysis, a large number of Lagrangian tracer particles were released at the inlet of the computational domain (upstream of the valve), and blood damage was evaluated along each trajectory for each model. We found that stress-based models predict higher levels of blood damage than the strain-based one. The same level of blood damage is observed in the two geometric configurations we considered, indicating that the adopted mechanical valve is primary risk factor for hemolysis.

AB - The paper reports the prediction of mechanical hemolysis by three different models for the case of blood flow through aortic valved prostheses. Two of the adopted models are based on the action of instantaneous shear stress on the blood cells (stress-based), while the third accounts for the finite response time of cell deformation and relaxation (strain-based). Two aortic Dacron grafts commonly adopted in clinical practice are considered, and both are equipped with a bileaflet mechanical valve. One of the grafts reproduces the three sinuses of Valsalva, while the other is a straight tube. A direct numerical simulation approach is utilized to solve the complex fluid-structure-interaction problem and obtain detailed information of the flow patterns. To evaluate hemolysis, a large number of Lagrangian tracer particles were released at the inlet of the computational domain (upstream of the valve), and blood damage was evaluated along each trajectory for each model. We found that stress-based models predict higher levels of blood damage than the strain-based one. The same level of blood damage is observed in the two geometric configurations we considered, indicating that the adopted mechanical valve is primary risk factor for hemolysis.

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KW - IR-89911

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