Computer modeling of Motor Cortex Stimulation: Effects of Anodal, Cathodal and Bipolar Stimulation

L. Manola, J. Holsheimer, Jan R. Buitenweg, Petrus H. Veltink

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    Abstract

    Motor cortex stimulation (MCS) is a promising clinical technique for treatment of chronic pain. However, optimization of the therapeutic efficacy is hampered since it is not known how electrically activated neural structures in the motor cortex can induce pain relief. Furthermore, multiple neural elements are present in the motor cortex such as cell bodies, dendrites and axons which are parallel or perpendicular to the cortical layers. Which of these neural elements are immediately excited by the electrical pulses in MCS depends on positioning of anodal and cathodal electrodes and stimulation parameters. A proper insight on these effects would be useful for peroperative decision making on electrode positioning and for the interpretation of stimulation results after implantation. Computational modeling studies can help to identify the effects of electrical stimulation on cortical neural tissue, elucidate mechanisms of action and ultimately to optimize the therapy
    Original languageUndefined
    Title of host publicationProceedings of the 8th world congres INS (International Neuromodulation Society) and 11th annual meeting NANS
    Place of PublicationSan Francisco, USA
    PublisherInternational Neuromodulation Society
    Pages119-119
    Number of pages1
    ISBN (Print)not assigned
    Publication statusPublished - Dec 2007
    EventThe 8th world congres INS (International Neuromodulation Society) and 11th annual meeting NANS, Acapulco, Mexico: INS Congress Proceedings 2007 - San Francisco, USA
    Duration: 9 Dec 200712 Dec 2007

    Publication series

    Name
    PublisherInternational Neuromodulation Society
    Number7
    VolumeINS Co

    Conference

    ConferenceThe 8th world congres INS (International Neuromodulation Society) and 11th annual meeting NANS, Acapulco, Mexico
    CitySan Francisco, USA
    Period9/12/0712/12/07

    Keywords

    • EWI-11900
    • METIS-246015
    • IR-64624
    • BSS-Central mechanisms underlying chronic pain

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