Concentration polarization in nanochannel DNA electrophoresis

P. Dubsky; Siddhartha Das; Albert van den Berg; Jan C.T. Eijkel

Concentration polarization in nanochannel DNA electrophoresis

P. Dubsky, Siddhartha Das, Albert van den Berg, Jan C.T. Eijkel

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

1 Downloads (Pure)

Abstract

We demonstrate that the large field electrophoresis of a single DNA molecule in nanofluidic systems is accompanied by concentration polarization. We illustrate this phenomena by utilizing our electrophoretic simulation tool SIMUL. First we in-vestigate a simple system with univalent strong electrolyte as a bulk solution. Second, a more complicated system with buf-fering background electrolyte is examined. Concentration polarization in the vicinity of the DNA is observed in both the sys-tems. The practical impact of such observations are also discussed.

Original language	Undefined
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011
Place of Publication	Washington
Publisher	The Chemical and Biological Microsystems Society
Pages	212-214
Number of pages	3
ISBN (Print)	978-0-979-8064-4-5
Publication status	Published - 2 Oct 2011
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011 - Seattle, United States Duration: 2 Oct 2011 → 6 Oct 2011 Conference number: 15 https://microtasconferences.org/microtas2011/

Publication series

Name
Publisher	Chemical and Biological Microsystems Society
ISSN (Print)	1556-5904

Conference

Conference	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011
Abbreviated title	MicroTAS
Country/Territory	United States
City	Seattle
Period	2/10/11 → 6/10/11
Internet address	https://microtasconferences.org/microtas2011/

Keywords

METIS-281589
Nanochannel
DNA
EWI-20882
IR-78650
Electrophoresis
Concentration polarization

Access to Document

http://eprints.eemcs.utwente.nl/secure2/20882/01/072_0402.pdf

Cite this

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title = "Concentration polarization in nanochannel DNA electrophoresis",

abstract = "We demonstrate that the large field electrophoresis of a single DNA molecule in nanofluidic systems is accompanied by concentration polarization. We illustrate this phenomena by utilizing our electrophoretic simulation tool SIMUL. First we in-vestigate a simple system with univalent strong electrolyte as a bulk solution. Second, a more complicated system with buf-fering background electrolyte is examined. Concentration polarization in the vicinity of the DNA is observed in both the sys-tems. The practical impact of such observations are also discussed.",

keywords = "METIS-281589, Nanochannel, DNA, EWI-20882, IR-78650, Electrophoresis, Concentration polarization",

author = "P. Dubsky and Siddhartha Das and {van den Berg}, Albert and Eijkel, {Jan C.T.}",

year = "2011",

month = oct,

day = "2",

language = "Undefined",

isbn = "978-0-979-8064-4-5",

publisher = "The Chemical and Biological Microsystems Society",

pages = "212--214",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011",

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Dubsky, P, Das, S, van den Berg, A & Eijkel, JCT 2011, Concentration polarization in nanochannel DNA electrophoresis. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011. The Chemical and Biological Microsystems Society, Washington, pp. 212-214, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011, Seattle, Washington, United States, 2/10/11. <http://eprints.eemcs.utwente.nl/secure2/20882/01/072_0402.pdf>

Concentration polarization in nanochannel DNA electrophoresis. / Dubsky, P.; Das, Siddhartha; van den Berg, Albert et al.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011. Washington : The Chemical and Biological Microsystems Society, 2011. p. 212-214.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Concentration polarization in nanochannel DNA electrophoresis

AU - Dubsky, P.

AU - Das, Siddhartha

AU - van den Berg, Albert

AU - Eijkel, Jan C.T.

N1 - Conference code: 15

PY - 2011/10/2

Y1 - 2011/10/2

N2 - We demonstrate that the large field electrophoresis of a single DNA molecule in nanofluidic systems is accompanied by concentration polarization. We illustrate this phenomena by utilizing our electrophoretic simulation tool SIMUL. First we in-vestigate a simple system with univalent strong electrolyte as a bulk solution. Second, a more complicated system with buf-fering background electrolyte is examined. Concentration polarization in the vicinity of the DNA is observed in both the sys-tems. The practical impact of such observations are also discussed.

AB - We demonstrate that the large field electrophoresis of a single DNA molecule in nanofluidic systems is accompanied by concentration polarization. We illustrate this phenomena by utilizing our electrophoretic simulation tool SIMUL. First we in-vestigate a simple system with univalent strong electrolyte as a bulk solution. Second, a more complicated system with buf-fering background electrolyte is examined. Concentration polarization in the vicinity of the DNA is observed in both the sys-tems. The practical impact of such observations are also discussed.

KW - METIS-281589

KW - Nanochannel

KW - DNA

KW - EWI-20882

KW - IR-78650

KW - Electrophoresis

KW - Concentration polarization

M3 - Conference contribution

SN - 978-0-979-8064-4-5

SP - 212

EP - 214

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011

PB - The Chemical and Biological Microsystems Society

CY - Washington

Y2 - 2 October 2011 through 6 October 2011

ER -