Concise Review: Organ Engineering: Design, Technology, and Integration

G. Kaushik, Jeroen Christianus Hermanus Leijten, A. Khademhosseini

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed. Stem Cells 2016
Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalStem cells
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • METIS-318258
  • IR-101758

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