Abstract
Here we introduce a versatile flow patterning technique (Fig1b) for pillar-less patterning of straight (Fig3) and highly curved (Fig2) gel geometries to test a wide range of in vivo-like vessel sprouting conditions. Much current research focuses on implementing angiogenesis on Organ-on-Chip (OOC) platforms for investigation of the role of signaling proteins[1] and the role of angiogenesis in cancer treatment[2]. Our technique avoids using pillars to confine the gel (Fig 1a) and thereby reduces the contact area between the growing spouts and the unnaturally stiff chip material which is known to affect migration rate of adherent cell types[4].
| Original language | English |
|---|---|
| Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Editors | Abraham Lee, Don DeVoe |
| Publisher | The Chemical and Biological Microsystems Society |
| Pages | 1074- |
| Number of pages | 2 |
| ISBN (Print) | 978-0-692-94183-6 |
| Publication status | Published - 22 Oct 2017 |
| Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 Conference number: 21 https://www.microtas2017.org/ |
Publication series
| Name | International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS) |
|---|---|
| Volume | 2017 |
| ISSN (Print) | 1556-5904 |
Conference
| Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 |
|---|---|
| Abbreviated title | MicroTAS |
| Country/Territory | United States |
| City | Savannah |
| Period | 22/10/17 → 26/10/17 |
| Internet address |