Configurable gel geometry via flow patterning for angiogenisis assays

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Abstract

Here we introduce a versatile flow patterning technique (Fig1b) for pillar-less patterning of straight (Fig3) and highly curved (Fig2) gel geometries to test a wide range of in vivo-like vessel sprouting conditions. Much current research focuses on implementing angiogenesis on Organ-on-Chip (OOC) platforms for investigation of the role of signaling proteins[1] and the role of angiogenesis in cancer treatment[2]. Our technique avoids using pillars to confine the gel (Fig 1a) and thereby reduces the contact area between the growing spouts and the unnaturally stiff chip material which is known to affect migration rate of adherent cell types[4].
Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsAbraham Lee, Don DeVoe
PublisherThe Chemical and Biological Microsystems Society
Pages1074-
Number of pages2
ISBN (Print)978-0-692-94183-6
Publication statusPublished - 22 Oct 2017
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
https://www.microtas2017.org/

Publication series

NameInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS)
Volume2017
ISSN (Print)1556-5904

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
Abbreviated titleMicroTAS
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

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  • Cite this

    Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J., & van den Berg, A. (2017). Configurable gel geometry via flow patterning for angiogenisis assays. In A. Lee, & D. D. (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1074-). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.