Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes

Morten B. Hansen, Ethlinn Van Gaal, Inge Minten, Gert Storm, Jan C.M. Van Hest, Dennis W.P.M. Löwik*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells.

Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalJournal of controlled release
Volume164
Issue number1
DOIs
Publication statusPublished - 28 Nov 2012

Keywords

  • Activatable cellular transduction
  • Cell penetrating peptide
  • Liposomes
  • Peptide amphiphiles

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