TY - JOUR
T1 - Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes
AU - Hansen, Morten B.
AU - Van Gaal, Ethlinn
AU - Minten, Inge
AU - Storm, Gert
AU - Van Hest, Jan C.M.
AU - Löwik, Dennis W.P.M.
PY - 2012/11/28
Y1 - 2012/11/28
N2 - Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells.
AB - Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells.
KW - Activatable cellular transduction
KW - Cell penetrating peptide
KW - Liposomes
KW - Peptide amphiphiles
UR - http://www.scopus.com/inward/record.url?scp=84868546970&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2012.10.008
DO - 10.1016/j.jconrel.2012.10.008
M3 - Article
C2 - 23085152
AN - SCOPUS:84868546970
VL - 164
SP - 87
EP - 94
JO - Journal of controlled release
JF - Journal of controlled release
SN - 0168-3659
IS - 1
ER -