Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

Shuqin Cao; Sandro Peeters; Sandra Michel-Souzy; Naomi Hamelmann; Jos M.J. Paulusse; Liu Lin Yang; Jeroen J.L.M. Cornelissen

doi:10.1039/d2tb02688k

Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

Shuqin Cao, Sandro Peeters, Sandra Michel-Souzy, Naomi Hamelmann, Jos M.J. Paulusse, Liu Lin Yang^*, Jeroen J.L.M. Cornelissen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.

Original language	English
Pages (from-to)	7933-7941
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	11
Issue number	33
DOIs	https://doi.org/10.1039/d2tb02688k
Publication status	Published - 6 Jun 2023

Keywords

UT-Hybrid-D

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10.1039/d2tb02688kLicence: CC BY

Construction of viralFinal published version, 1.97 MBLicence: CC BY

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title = "Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue",

abstract = "A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.",

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doi = "10.1039/d2tb02688k",

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T1 - Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

AU - Cao, Shuqin

AU - Peeters, Sandro

AU - Michel-Souzy, Sandra

AU - Hamelmann, Naomi

AU - Paulusse, Jos M.J.

AU - Yang, Liu Lin

AU - Cornelissen, Jeroen J.L.M.

PY - 2023/6/6

Y1 - 2023/6/6

N2 - A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.

AB - A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.

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IS - 33

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Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

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