Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

Shuqin Cao, Sandro Peeters, Sandra Michel-Souzy, Naomi Hamelmann, Jos M.J. Paulusse, Liu Lin Yang*, Jeroen J.L.M. Cornelissen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.

Original languageEnglish
Pages (from-to)7933-7941
Number of pages9
JournalJournal of Materials Chemistry B
Volume11
Issue number33
DOIs
Publication statusPublished - 6 Jun 2023

Keywords

  • UT-Hybrid-D

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